ArticleFrontiers in cell and developmental biology2026
Lineage tracing reveals photoreceptor precursor cell subpopulations that contribute to murine retinogenesis.
Article in Frontiers in cell and developmental biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Cell-based therapies hold great promise for treating late-stage retinal degenerative diseases. However, photoreceptor cell transplantation has been limited by poor cellular integration, suggesting that an ideal population of donor cells has not yet been defined. Methods: Here, we utilized single-cell RNA-sequencing and lineage tracing to assess the heterogeneity of photoreceptor precursor cells during murine retinal development. Results: Subgroup analysis revealed three transcriptionally distinct populations of Conclusion: These findings highlight the heterogeneity of neonatal photoreceptor precursor cells, and could help inform future strategies to isolate an optimal population of cells for retinal regeneration.
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