Evidence map›Paper›PMID 42326003›Full record

ReviewFrontiers in cell and developmental biology2026

Insights into oncovirus-driven tumor dynamics: a perspective from intravital imaging.

Hyeri Kim, Dohun Pyeon, Sangbum Park

Abstract readReview
In one paragraph

Review in Frontiers in cell and developmental biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Hyeri KimInstitute for Quantitative Health Science and Engineering, Michigan State University, East Lansing, MI, United States.
Dohun PyeonDepartment of Microbiology, Genetics, and Immunology, Michigan State University, East Lansing, MI, United States.
Sangbum ParkInstitute for Quantitative Health Science and Engineering, Michigan State University, East Lansing, MI, United States.

Funding

Tick Saliva and Pathogen TransmissionR01AI134696 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI Joao Pedra · 2018 to 2026
$5.1M
Chemokine-mediated antigen-specific T cell responses and immunotherapies to treat head and neck cancerR01DE029524 · NIDCR · MICHIGAN STATE UNIVERSITY · PI PYEON, DOHUN, SPANOS, WILLIAM CHARLES · 2020 to 2024
$3.2M
Understanding immune-epithelial interactions during wound repair in live mammalsR01AR083086 · NIAMS · MICHIGAN STATE UNIVERSITY · PI Sangbum Park · 2023 to 2026
$1.9M
Immune receptor degradation for immune evasion of head and neck cancerR01DE033797 · NIDCR · HENRY FORD HEALTH + MICHIGAN STATE UNIVERSITY HEALTH SCIENCES · PI QING-SHENG MI, Dohun Pyeon · 2025 to 2026
$1.3M
NIAID NIH HHS R01 AI134696NIAMS NIH HHS R01 AR083086NIDCR NIH HHS R01 DE029524NIDCR NIH HHS R01 DE033797
6 · The paper itself

Abstract

The tumor microenvironment (TME) is a critical determinant of cancer initiation, progression, and therapeutic response. It comprises not only tumor cells but also immune cells, stromal components, and vasculature that interact through complex molecular signaling networks. In cancers driven by oncoviruses, viral infection represents a unique biological factor that profoundly influences TME formation and remodeling, thereby shaping distinct features such as immune evasion, chronic inflammation, and stromal and vascular reprogramming. Conventional approaches provide valuable insights into the static composition of the TME, but are inherently limited in capturing dynamic cellular behaviors, including immune cell migration, spatiotemporal immune remodeling, and CD8

Indexed as

head and neck cancerHPVimmune cell infiltrationintravital imagingmultiphoton microscopyoncovirustumor microenvironment

Identifiers

PMID42326003
PMCPMC13275403

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.