Evidence map›Paper›PMID 42325993›Full record

ArticleCell press blue2026

Quantitative 3D histology reveals localized immune remodeling during early pancreatic cancer progression.

Ashley L Kiemen, Valentina Matos, Cristina Almagro-Pérez, André Forjaz, Alicia M Braxton Hickman, Lucie Dequiedt, Jeeun Parksong, Courtney D Cannon, Xuan Yuan, Sarah M Shin and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell press blue, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Ashley L KiemenDepartment of Pathology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Valentina MatosDepartment of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD, USA.
Cristina Almagro-PérezDepartment of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD, USA.
André ForjazDepartment of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD, USA.
Alicia M Braxton HickmanDepartment of Pathology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Lucie DequiedtDepartment of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD, USA.
Jeeun ParksongDepartment of Pathology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Courtney D CannonSidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Xuan YuanSidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Sarah M ShinSidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Jaanvi Mahesh BabuDepartment of Pathology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Elizabeth D ThompsonDepartment of Pathology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Toby C CornishDepartment of Pathology and Data Science Institute, Medical College of Wisconsin, Milwaukee, WI, USA.
Won Jin HoSidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Laura D WoodDepartment of Pathology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Pei-Hsun WuDepartment of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD, USA.
Arrate Muñoz BarrutiaNeuroscience and Life Science Department, Universidad Carlos III de Madrid, Getafe, Spain.
Ralph H HrubanDepartment of Pathology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Denis WirtzDepartment of Pathology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins School of Medicine, Baltimore, MD, USA.

Funding

Tech Core 2U54CA268083 · NCI · JOHNS HOPKINS UNIVERSITY · PI Pei-Hsun wu · 2022 to 2026
$10.2M
Tumor Microenvironment Crosstalk Drives Early Lesions in Pancreatic CancerU54CA274371 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Elana Fertig · 2022 to 2026
$9.5M
T32: Predoctoral and Postdoctoral Training Program in Nanotechnology for Cancer ResearchT32CA153952 · NCI · JOHNS HOPKINS UNIVERSITY · PI Denis Wirtz · 2015 to 2026
$3.5M
Three-dimensional maps of senescence in the human pancreasUG3CA275681 · NCI · JOHNS HOPKINS UNIVERSITY · PI WU, PEI-HSUN · 2022 to 2023
$1.1M
Mass Cytometer CyTOF XT for Single-Cell BiologyS10OD034407 · OD · JOHNS HOPKINS UNIVERSITY · PI HO, WON JIN · 2024 to 2024
$499k
NCI NIH HHS T32 CA153952NCI NIH HHS U54 CA268083NCI NIH HHS U54 CA274371NCI NIH HHS UG3 CA275681NIH HHS S10 OD034407
6 · The paper itself

Abstract

Pancreatic cancer features a dense, immune-excluded stroma whose origins remain unclear. In this work, we extended CODA, a cellular-resolution three-dimensional (3D) histology pipeline, to map inflammation around more than 1,000 pancreatic precancers in large human pancreas specimens. Bulk analyses reproduce prior associations between overall inflammation and precancer burden, fibrosis, and acinar dropout, implicating ductal obstruction and stromal remodeling in early immune changes. Crucially, 3D mapping reveals that inflammation around individual precancers is highly heterogeneous, with immune hotspots and cold spots interchanging over tens of microns. Hotspots are found around regions of higher-grade dysplasia and ductal obstruction and are enriched for regulatory T cells and macrophages, indicating focal emergence of immunosuppression at the precancer stage. Integration with spatially resolved DNA sequencing implicated mutation in inflammation. These results position 3D mapping as a framework to identify rare sites of active microenvironmental priming and highlight focal immunosuppressive niches as candidate sites for early interception.

Identifiers

PMID42325993
PMCPMC13278467

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.