ArticleFrontiers in psychiatry2026
Additive impulsivity and emotion dysregulation in adolescents with comorbid bipolar and substance use disorder: a cross-sectional factorial study.
Article in Frontiers in psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Comorbid bipolar disorder (BD) and substance use disorder (SUD) in adolescence is associated with poor clinical outcomes, yet the independent and interactive contributions of impulsivity and emotion dysregulation remain poorly understood. Methods: This cross-sectional study employed a 2 × 2 factorial design to examine impulsivity, measured with the Barratt Impulsiveness Scale-11, and emotion regulation difficulties, measured with the Difficulties in Emotion Regulation Scale, across four groups of adolescents (N = 128; aged 12-18 years): BD+SUD (n = 32), BD-only (n = 32), SUD-only (n = 32), and healthy controls (n = 32). All clinical participants were assessed during euthymia. Factorial analyses of covariance controlled for age, sex, residence, family structure, and income. Results: Significant BD × SUD interactions were found for emotion regulation, F(1,120) = 35.89, p < .001, ηp Discussion: These findings support an additive comorbidity model in which BD and SUD jointly amplify impulsivity and emotion dysregulation, and they highlight the need for integrated, impulsivity-focused interventions in adolescents with dual diagnoses.
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