Evidence map›Paper›PMID 42325975›Full record

ArticleFrontiers in psychiatry2026

The association of different dimensions of anhedonia in the relationship between depressive symptoms and self-harm in adolescents with mood disorders.

Jiping Xiao, Dandan Liu, Li Cheng, Mian Zhang, Ming Wu, Nan Du, Li Zhu, Daomin Zhu

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Article in Frontiers in psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

8 authors.

Jiping XiaoAffiliated Psychological Hospital of Anhui Medical University, Hefei, China.
Dandan LiuAffiliated Psychological Hospital of Anhui Medical University, Hefei, China.
Li ChengAffiliated Psychological Hospital of Anhui Medical University, Hefei, China.
Mian ZhangAffiliated Psychological Hospital of Anhui Medical University, Hefei, China.
Ming WuAffiliated Psychological Hospital of Anhui Medical University, Hefei, China.
Nan DuAffiliated Psychological Hospital of Anhui Medical University, Hefei, China.
Li ZhuAffiliated Psychological Hospital of Anhui Medical University, Hefei, China.
Daomin ZhuAffiliated Psychological Hospital of Anhui Medical University, Hefei, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: An increasing number of adolescents with mood disorders engage in self-harm. Anhedonia is independently associated with self-harm. Exploratory analyses in this cross-sectional study examined the associations of different dimensions of anhedonia in self-harm to provide additional theoretical support for self-harm intervention. Methods: This study recruited 252 adolescents aged 12-18 years with mood disorders, and divided them into high-risk (n=143) and low-risk (n=109) groups based on suicide risk, and recruited 120 normal control participants. Data collected included depressive and anxiety symptoms (HAMD-24, HAMA-14), different dimensions of anhedonia, including the anticipatory anhedonia (TEPS-A)and consummatory anhedonia (TEPS-C), Social Anhedonia (RSAS), and the somatic Anhedonia (RPAS), and suicidal ideation (PANSI), non-suicidal self-injury (NSSI), and suicide attempts (SA). Results: All anhedonia dimensions and self-harm indicators differed significantly across groups (high-risk > low-risk > controls, all P < 0.001). anticipatory anhedonia (TEPS-A) [B = -0.194, P = 0.043, 95% CI (-0.382, -0.006)] and consummatory anhedonia (TEPS-C) [B = -0.228, P = 0.016, 95% CI (-0.413, -0.042)] were independently and negatively associated with PANSI. Somatic anhedonia (RPAS) were independently and positively associated with NSSI [B = 0.642, P = 0.001, 95% CI (0.255, 1.030)] and SA (OR = 1.050, P = 0.024, 95% CI [1.006, 1.097]). Anticipatory anhedonia (TEPS-A) showed a significant indirect effect in the relationship between depressive symptoms and PANSI [B = 0.051, 95% CI (0.006, 0.105)]. Somatic anhedonia (RPAS) showed a significant indirect effect in the relationship between depressive symptoms and NSSI [B = 0.241, 95% CI (0.118, 0.389)], and together with NSSI and PANSI, formed a significant sequential indirect effect to SA [B = 0.0012, 95% CI (0.0002, 0.0026)]. Conclusion: Different anhedonia dimensions demonstrate distinct associations with self-harm: anticipatory anhedonia was associated with suicidal ideation, whereas somatic anhedonia connects to NSSI and suicide attempts. These findings support dimensional-specific clinical assessment and targeted interventions. Causal inference is not possible due to the cross-sectional design, and longitudinal studies are needed to establish temporal relationships and causal mechanisms.

Indexed as

adolescentsanhedoniamood disorders (MD)non-suicidal self-injury (NSSI)self-harmsuicide attempt (SA)suicide ideation

Identifiers

PMID42325975
PMCPMC13275427

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