ArticleFrontiers in molecular neuroscience2026
Glymphatic dysfunction and neuroinflammation in FXTAS: evidence from DTI-ALPS and gene expression analysis.
Article in Frontiers in molecular neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background and objectives: Fragile X-associated tremor/ataxia syndrome (FXTAS) is a late-onset neurodegenerative disorder that affects carriers of the Methods: We analyzed the DTI-ALPS index in 14 participants with FXTAS and 25 age- and sex-matched controls, and assessed the expression and pathway dysregulation of genes related to neuroinflammation and glymphatic function using Reactome analysis in postmortem brain tissue from 3 individuals with FXTAS and 12 controls and skin fibroblasts from 6 individuals with FXTAS and 3 controls. Results: The DTI-ALPS index was significantly lower in individuals with FXTAS compared to controls in the right but not left hemisphere ( Discussion: Our findings point at glymphatic system dysfunction and neuroinflammation in FXTAS pathophysiology, as evidenced by
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