ArticleFrontiers in allergy2026
Serological and biochemical characterization of Aspergillus fumigatus Asp f 10 as a potential diagnostic marker in ABPA and related respiratory diseases.
Article in Frontiers in allergy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Methods: We profiled the Results: Asp f 10 was identified as an extracellular IgG-reactive protease. Recombinant mature Asp f 10 exhibited folded conformation, structural stability, and gelatinolytic activity, whereas the full-length protein lacked defined structure. Both isoforms bound patient IgE and IgG; however, only Asp f 10-specific IgG responses were significantly elevated in ABPA and SAAS. ROC analysis demonstrated excellent diagnostic capacity for IgG (AUC = 0.90), far surpassing IgE (AUC = 0.54). Despite IgE recognition, mature Asp f 10 failed to induce histamine release, suggesting limited effector activity. Conclusion: Asp f 10 is a biologically active protease, and Asp f 10-specific IgG responses provide a robust biomarker for ABPA, outperforming IgE in diagnostic accuracy. Incorporating Asp f 10 into serological panels may improve differential diagnosis of
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