Trial reportDrug design, development and therapy2026
Efficacy and Safety of Ultrasound-Guided Erector Spinae Plane Block at Different Injection Depths for Percutaneous Kyphoplasty: A Randomized Controlled Trial.
Trial report in Drug design, development and therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
6 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Objective: To compare the analgesic efficacy and safety of deep, superficial and combined deep-superficial erector spinae plane block (ESPB) combined with subanesthetic-dose esketamine in patients undergoing percutaneous kyphoplasty (PKP). Patients and Methods: A total of 120 elderly patients with osteoporotic vertebral compression fractures and undergoing elective PKP were randomly divided into three groups (n=40 each): a deep ESPB group (D), a superficial ESPB group (S) and a combined deep-superficial ESPB group (C). All patients received intravenous esketamine (0.125 mg/kg) preoperatively. We recorded intraoperative and postoperative Visual Analogue Scale (VAS) scores, hemodynamic parameters, the onset time for sensory block, rescue analgesia requirements and adverse reactions. Results: The combined group exhibited significantly lower cumulative intraoperative pain (AUC: 0-4), fewer administrations of rescue analgesia, and more stable hemodynamics than the two single-depth groups (P<0.01 for all). Differences in postoperative analgesia were only observed at 6 hours, with no significant differences at 12 and 24 hours. No significant difference was found between the three groups in terms of the incidence of adverse reactions. Conclusion: Combined deep and superficial ESPB combined with subanesthetic-dose esketamine provides superior intraoperative analgesia and hemodynamic stability for patients with PKP, with a safety profile that is similar to single-depth blocks.
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