Evidence map›Paper›PMID 42325866›Full record

ArticleNeurobiology of sleep and circadian rhythms2026

The PER2:BRCA1:POU2F1(OCT-1) ternary complex represents a multi-component scaffold model for circadian gene regulation.

Elizaveta Kadukhina, Siqi Jia, Linda M Villa, Xiao Yi, Daniel G S Capelluto, Jonathan S Briganti, Anne M Brown, Carla V Finkielstein

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Article in Neurobiology of sleep and circadian rhythms, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Elizaveta KadukhinaFralin Biomedical Institute at Virginia Tech Carilion, Virginia Tech, Roanoke, VA, 24016, USA.
Siqi JiaFralin Biomedical Institute at Virginia Tech Carilion, Virginia Tech, Roanoke, VA, 24016, USA.
Linda M VillaDepartment of Biological Sciences, Blacksburg, VA, 24061, USA.
Xiao YiDepartment of Biological Sciences, Blacksburg, VA, 24061, USA.
Daniel G S CapellutoProtein Signaling Domains Laboratory, Department of Biological Sciences, Blacksburg, VA, 24061, USA.
Jonathan S BrigantiData Services, University Libraries, Virginia Tech, Blacksburg, VA, 24061, USA.
Anne M BrownData Services, University Libraries, Virginia Tech, Blacksburg, VA, 24061, USA.
Carla V FinkielsteinFralin Biomedical Institute at Virginia Tech Carilion, Virginia Tech, Roanoke, VA, 24016, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The circadian clock component PER2 coordinates daily oscillations in gene expression across multiple tissues, yet its role in assembling multi-protein regulatory complexes remains incompletely understood. Here, we report that PER2 nucleates a ternary complex with the tumor suppressor BRCA1 and the transcription factor POU2F1(OCT-1) to impose circadian control on target gene promoters. Using bacterial two-hybrid screening, we identified BRCA1 as a novel PER2-interacting protein. Biochemical mapping revealed that PER2 engages BRCA1 through multiple discrete binding interfaces: PER2 spanning residues 356-574 and 683-872 interact with both the N-terminal (1-400) and C-terminal BRCT (1670-1863) domains of BRCA1. Structural modeling predicted 361 residue contacts between PER2 and BRCA1, substantially more than the 74 contacts predicted for PER2:POU2F1(OCT-1), indicating differential affinities that enable ordered complex assembly. Sequential pull-down assays demonstrated that PER2, BRCA1, and POU domain form a stable ternary complex

Indexed as

BRCA1Circadian rhythmsEstrogen receptorPeriod 2POU2F1(OCT-1)Tumor suppressor

Identifiers

PMID42325866
PMCPMC13280575

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