ArticleTobacco induced diseases2026
Low systolic blood pressure increases risk of allergic rhinitis: Evidence from a bidirectional Mendelian randomization study accounting for smoking environment.
Article in Tobacco induced diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
introductionAllergic rhinitis (AR) is one of the most common diseases in adults. Dust and secondhand smoke in the air can both trigger AR and elevated blood pressure. The objective of this study was to assess the impact of systolic blood pressure (SBP) on the risk of AR using a bidirectional two-sample Mendelian randomization (MR) framework.
methodsSummary-level genome-wide association study data for SBP and AR were retrieved from the MR-Base platform. Single-nucleotide polymorphisms (SNPs) associated with SBP as exposure at genome-wide significance (p<5×10
resultsA total of 421 independent SNPs associated with SBP were included in the forward MR analysis. All three methods consistently indicated that genetically lower SBP is associated with an increased risk of AR (IVW odds ratio, OR=0.9997; 95% CI: 0.9995-0.9999; weighted median OR=0.9998; 95% CI: 0.9995-1.0001; MR-Egger OR=0.9996; 95% CI: 0.9990-1.0001). Reverse MR analysis provided no evidence that genetic liability to AR influences SBP.
conclusionsThese findings provide genetic evidence for a relationship in which lower systolic blood pressure increases susceptibility to allergic rhinitis.
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