ArticleAmerican journal of translational research2026
The impact of nutritional risk and sarcopenia on postoperative complications and survival outcomes in elderly patients undergoing colorectal cancer surgery: a retrospective cohort study.
Article in American journal of translational research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveTo investigate individual and combined effects of preoperative nutritional risk and sarcopenia on postoperative complications and survival in elderly colorectal cancer (CRC) patients.
methodsData from 260 elderly patients (>60 years) undergoing radical CRC surgery (2022-2024) were retrospectively analyzed. Nutritional risk was assessed by NRS-2002 (score ≥3). Sarcopenia was diagnosed by AWGS 2019 criteria (handgrip strength + CT muscle index). Patients were grouped into No-risk, Nutritional risk only, Sarcopenia only, and Combined. OUTCOMES: Overall (Clavien-Dindo ≥II) and severe (≥IIIa) complications, and overall survival. Multivariate Cox regression was used.
resultsMean age 68.08±5.32 years. Nutritional risk prevalence 44.6% (116/260), sarcopenia 28.5% (74/260), coexistence 16.2% (42/260). The Combined group had highest overall complication rate (64.3% vs. 15.2% in No-risk, P<0.001) and severe complication rate (23.8% vs. 7.1%, P = 0.007). Median follow-up 18 months; Combined group lowest 18-month survival (69.0% vs. 96.4%, P<0.001). Multivariate Cox regression (adjusting for age, sex, BMI) showed Nutritional risk only (HR = 3.954, 95% CI: 1.369-11.420, P = 0.011) and Sarcopenia only (HR = 4.095, 95% CI: 1.181-14.195, P = 0.026) were poor prognostic indicators. Coexistence was the strongest predictor (HR = 10.173, 95% CI: 3.699-27.977, P<0.001).
conclusionPreoperative coexistence of nutritional risk and sarcopenia significantly increases complications and reduces survival in elderly CRC patients, with risks far exceeding single factors. Routine dual assessment and intensive prehabilitation should be implemented.
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