ReviewAmerican journal of translational research2026
Latest clinical evidence and strategies for endoscopic intratympanic steroid injection in the treatment of sudden sensorineural hearing loss.
Review in American journal of translational research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Sudden sensorineural hearing loss (SSNHL) is a common otolaryngological emergency. Its pathogenesis is associated with vascular dysfunction, viral infection, and autoimmune abnormalities. In recent years, endoscopic intratympanic steroid injection (ITSI), as a minimally invasive procedure, has been increasingly applied in the treatment of SSNHL. It presents prominent clinical advantages, especially for patients with contraindications to systemic steroid therapy or refractory cases unresponsive to conventional treatment. Herein, we systematically review the pathogenesis, epidemiological characteristics, diagnostic approaches and therapeutic regimens of SSNHL, and further discuss the controversies and future research prospects of endoscopic ITSI. Based on evidence-based medical findings, this article summarizes the efficacy and safety of endoscopic ITSI in enhancing hearing recovery in patients with SSNHL. Nevertheless, further optimization of surgical procedures and individualized therapeutic regimens is still required. Future research directions include the development of novel drug carriers, exploration of gene therapy, and application of artificial intelligence-assisted diagnosis, aiming to advance precise and individualized treatment for SSNHL.
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