ArticleF&S reports2026
Simultaneous trophectoderm biopsies enable preimplantation genetic testing for monogenic disorders in de novo case of incontinentia pigmenti: case report.
Article in F&S reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: To describe the use of two simultaneous trophectoderm biopsies as a method to establish linkage analysis for preimplantation genetic testing for monogenic disorders (PGT-M) test development in a case of de novo incontinentia pigmenti (IP). Design: Case report. Subject: A 29-year-old nulligravid woman with de novo IP, confirmed to have the common, large deletion of exons 4-10 in the Exposure: Two simultaneous trophectoderm biopsies from a minimum of four embryos were obtained to enable two independent deoxyribonucleic acid preparations. This approach was utilized to complete linkage analysis, facilitating successful test development for PGT-M. Main Outcome Measures: PGT-M test development and subsequent intracytoplasmic sperm injection/PGT-M cycle targeting the Results: PGT-M test development was successful. The patient underwent two antagonist stimulation protocols with intracytoplasmic sperm injection and PGT-M, yielding 10 euploid embryos that tested negative for the Conclusions: PGT-M for de novo IP is particularly challenging given the presence of the
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