Amoxicillin Direct Oral Challenge in Hospitalized Patients With High-Risk Allergic Reactions, in a Pharmacist-Directed Program.

Bryan Le, Shyam Joshi, Kendall Tucker, Young Yoon Ham

Abstract read

In one paragraph

Article in Open forum infectious diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Bryan LeDepartment of Pharmacy Practice, Oregon State University College of Pharmacy, Portland, Oregon, USA.

Shyam JoshiSection of Allergy and Immunology, Oregon Health & Science University, Portland, Oregon, USA.

Kendall TuckerDepartment of Pharmacy Practice, Oregon State University College of Pharmacy, Portland, Oregon, USA.ORCID https://orcid.org/0000-0001-5868-0449

Young Yoon HamDepartment of Pharmacy, Oregon Health & Science University, Portland, Oregon, USA.ORCID https://orcid.org/0000-0002-5644-4896

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In 169 hospitalized adults with penicillin allergy histories, either through interview or listed in the electronic medical record of urticaria, angioedema, anaphylaxis, and/or shortness of breath at least 10 years ago, 94.1% tolerated a direct oral amoxicillin challenge led by a non-allergy specialist and were delabeled. Mild reactions occurred in 5.9%, with no severe events. This safe, effective approach may improve antibiotic stewardship, reduce costs, and support broader implementation over penicillin skin testing.

Indexed as

antimicrobial stewardshipdirect oral challengehigh-risk reactioninpatient evaluationpenicillin allergy

Identifiers

PMID42325646

DOI10.1093/ofid/ofag344

PMCPMC13276866

What OpenQuestion holds

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LicenceCC BY

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.