ArticleCase reports in oncology
Potential Influence of Duchenne Muscular Dystrophy Carrier on Breast Cancer Treatment-Related Cardiomyopathy: A Case Report.
Article in Case reports in oncology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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2 authors.
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Abstract
Introduction: Carriers of Duchenne muscular dystrophy (DMD) and other inherited myopathies are at risk of cardiomyopathy, and HER2-targeted therapies for breast cancer are also associated with cardiotoxicity. The coexistence of these conditions presents a novel clinical challenge. Standard baseline cardiac evaluations prior to HER2-targeted therapy do not routinely detect inherited cardiomyopathies, and genetic risk is not currently incorporated into pretreatment assessment. Case Report: We report the case of a woman in her 30s with HER2-positive breast cancer with baseline borderline low global longitudinal strain who was incidentally identified as a carrier of a DMD gene mutation after her son was diagnosed with DMD and developed an asymptomatic decline in left ventricular ejection fraction during treatment. Conclusion: This case highlights the potential role of increased cardiac surveillance and consideration of cardioprotective medications and genetic screening in patients with baseline abnormal echocardiograms prior to receiving cardiotoxic cancer therapies.
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