ArticleCase reports in oncology
Chemo- and Immunotherapy in a Patient with Anti-TIF1γ-Positive Paraneoplastic Dermatomyositis in Adenocarcinoma of Unknown Primary Origin: A Challenging Path from Diagnosis to Treatment - A Case Report.
Article in Case reports in oncology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: A 35-year-old female patient presenting with photosensitive erythema initially consulted a general practitioner. After a dermatological evaluation, she was diagnosed with anti-TIF1γ-positive dermatomyositis (DM). Case Presentation: Due to a painful axillary lymph node, further ultrasound investigation led to the diagnosis of adenocarcinoma of unknown primary origin with paraneoplastic DM, initiating a complex, interdisciplinary treatment approach. A novel approach was initiating an immunotherapy due to cancer despite a paraneoplastic autoimmune disease, which adds to the literature that immunotherapy is not generally contraindicated in these patients. The treatment protocol was found in a combination of dose-dense corticosteroids, chemotherapy, immunotherapy, surgery, and radiotherapy. Conclusion: The treatment protocol led to a complete remission of both DM and neoplastic disease. This case underlines the importance of an individual and careful interdisciplinary treatment protocol with regularly evaluating the therapeutic outcome of symptoms and adverse effects.
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