Evidence map›Paper›PMID 42325569›Full record

ArticleiScience2026

SynCAR platform for capturing neuronal synaptic proteopathic seeds.

Rebecca M Sebastian, Robert Kupp, Dhaval Nanavati, Iwan Parfentev, Thomas J Krzystek, Nandini Romanul, Kiran Yanamandra, Christina N Preiss, Justine D Manos, Hai-Yan Wu and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Rebecca M SebastianAbbVie, Cambridge Research Center, 200 Sidney Street, Cambridge, MA 02139, USA.
Robert KuppAbbVie, Bay Area, 1000 Gateway Blvd, South San Francisco, CA 94080, USA.
Dhaval NanavatiAbbVie, Bioresearch Center, 100 Research Drive, Worcester, MA 01605, USA.
Iwan ParfentevAbbVie Deutschland GmbH & Co. KG, Neuroscience Bioinformatics, Genomics Research Center, Knollstrasse, Ludwigshafen 67061, Germany.
Thomas J KrzystekAbbVie, Cambridge Research Center, 200 Sidney Street, Cambridge, MA 02139, USA.
Nandini RomanulAbbVie, Cambridge Research Center, 200 Sidney Street, Cambridge, MA 02139, USA.
Kiran YanamandraAbbVie, Cambridge Research Center, 200 Sidney Street, Cambridge, MA 02139, USA.
Christina N PreissAbbVie, Cambridge Research Center, 200 Sidney Street, Cambridge, MA 02139, USA.
Justine D ManosAbbVie, Cambridge Research Center, 200 Sidney Street, Cambridge, MA 02139, USA.
Hai-Yan WuAbbVie, Bioresearch Center, 100 Research Drive, Worcester, MA 01605, USA.
Alexandra VolkovaAbbVie, Cambridge Research Center, 200 Sidney Street, Cambridge, MA 02139, USA.
Steven CrescentiAbbVie, Cambridge Research Center, 200 Sidney Street, Cambridge, MA 02139, USA.
Katherine TittertonAbbVie, Cambridge Research Center, 200 Sidney Street, Cambridge, MA 02139, USA.
Alessandra M WelkerAbbVie, Cambridge Research Center, 200 Sidney Street, Cambridge, MA 02139, USA.
Matt TownsendAbbVie, Cambridge Research Center, 200 Sidney Street, Cambridge, MA 02139, USA.
Eric KarranAbbVie, Cambridge Research Center, 200 Sidney Street, Cambridge, MA 02139, USA.
Xavier LangloisAbbVie, Cambridge Research Center, 200 Sidney Street, Cambridge, MA 02139, USA.
Jessica W WuAbbVie, Cambridge Research Center, 200 Sidney Street, Cambridge, MA 02139, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Synaptic proteins are critical for maintaining healthy neuronal transmission but can also drive prion-like

Indexed as

Cell biologyMolecular biologyNeuroscience

Identifiers

PMID42325569
PMCPMC13276770

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.