Evidence map›Paper›PMID 42325274›Full record

ArticleiScience2026

HERC4 suppresses colorectal cancer progression by promoting STAT3 ubiquitination.

Lanzhu Jiang, Kaidi Qin, Yuan Jin, Tong Zhu, Tianci Xie, Lanlan Yin, Yu Deng, Fayong Hu, Qi Wu, Zilong Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Lanzhu JiangDepartment of Gastrointestinal Surgery, Jingzhou Hospital Affiliated to Yangtze University, Jingbei Branch, No. 26 Chuyuan Avenue, Jingzhou District, Jingzhou, Hubei 434000, China.
Kaidi QinDepartment of Gastrointestinal Surgery, Jingzhou Hospital Affiliated to Yangtze University, Jingbei Branch, No. 26 Chuyuan Avenue, Jingzhou District, Jingzhou, Hubei 434000, China.
Yuan JinDepartment of Gastrointestinal Surgery, Jingzhou Hospital Affiliated to Yangtze University, Jingbei Branch, No. 26 Chuyuan Avenue, Jingzhou District, Jingzhou, Hubei 434000, China.
Tong ZhuMolecular Medicine Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, P.R. China.
Tianci XieMolecular Medicine Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, P.R. China.
Lanlan YinMolecular Medicine Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, P.R. China.
Yu DengDepartment of GI Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, P.R. China.
Fayong HuDepartment of GI Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, P.R. China.
Qi WuMolecular Medicine Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, P.R. China.
Zilong ZhangDepartment of Gastrointestinal Surgery, Jingzhou Hospital Affiliated to Yangtze University, Jingbei Branch, No. 26 Chuyuan Avenue, Jingzhou District, Jingzhou, Hubei 434000, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ubiquitination, a critical post-translational modification, regulates diverse cellular processes including protein degradation, signal transduction, and cell cycle progression. Dysregulation of the ubiquitin system is closely associated with tumor development and progression. HERC4, a member of the HECT-type E3 ubiquitin ligase family, remains poorly characterized in colorectal cancer (CRC). In this study, we report that HERC4 is significantly downregulated in CRC tissues and is associated with unfavorable patient prognosis. Functional assays demonstrate that HERC4 suppresses CRC cell proliferation both

Indexed as

biochemistrybiological sciencescancer

Identifiers

PMID42325274
PMCPMC13276532

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.