Efficacy and Safety of Underwater Versus Conventional Cold Snare Polypectomy for Small Colorectal Polyps: A Meta-Analysis of Randomized Controlled Trials.

Hamza Altal, Mohammad Darweesh, Saba Daher, Usama Abu Heija, Chakradhar Reddy

Abstract read

In one paragraph

Article in Gastroenterology research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Hamza AltalDepartment of Internal Medicine, East Tennessee State University Quillen College of Medicine, Johnson City, TN, USA.

Mohammad DarweeshDepartment of Internal Medicine, Division of Gastroenterology, East Tennessee State University Quillen College of Medicine, Johnson City, TN, USA.

Saba DaherDepartment of Internal Medicine, East Tennessee State University Quillen College of Medicine, Johnson City, TN, USA.

Usama Abu HeijaDepartment of Internal Medicine, Division of Gastroenterology, East Tennessee State University Quillen College of Medicine, Johnson City, TN, USA.

Chakradhar ReddyDepartment of Internal Medicine, Division of Gastroenterology, East Tennessee State University Quillen College of Medicine, Johnson City, TN, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Conventional cold snare polypectomy (CCSP) is the standard technique for removal of small non-pedunculated colorectal polyps. However, incomplete resection remains a concern. Recent data suggested that underwater cold snare polypectomy (UCSP) with no submucosal injection may enhance resection depth and histologic clearance. We aimed to compare the two polypectomy techniques with emphasis on efficacy and safety. Methods: We systematically searched PubMed, Embase, Cochrane Central, and ClinicalTrials.gov from inception through March 2026, for randomized controlled trials (RCTs) comparing UCSP and CCSP for 4-10 mm non-pedunculated colorectal polyps. The primary outcome was Results: Three RCTs met criteria (n = 822 polyps, total; UCSP 418, CCSP 404). Conclusions: UCSP improves

Indexed as

Cold snare polypectomyColorectal polypsMeta-analysisR0 resectionRandomized controlled trialUnderwater cold snare polypectomy

Identifiers

PMID42325218

DOI10.14740/gr2146

PMCPMC13278694

What OpenQuestion holds

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LicenceCC BY

Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.