Evidence map›Paper›PMID 42325096›Full record

ArticlePaediatric anaesthesia2026

Pharmacokinetics of Intravenous Melatonin in Preschool-Aged Pediatric Surgical Patients.

Anne Louise de Barros Garioud, Arash Afshari, Lau Romlund Halgreen, Kristian Østergaard Nielsen, Lars Peter Kloster Andersen

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Paediatric anaesthesia, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05541276 (MELAtonin for Prevention of Postoperative Agitation and Emergence Delirium in Children. The MELA-PAED Trial), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05541276 phase3recruitingnot on this map

MELAtonin for Prevention of Postoperative Agitation and Emergence Delirium in Children. The MELA-PAED Trial: a Randomized, Double-blind, Placebo-controlled Trial.

TypeinterventionalSponsorArash AfshariRan2025 to 2027Enrolled676ConditionsEmergence DeliriumArmsMelatonin, Isotonic sodium chloride solution
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Anne Louise de Barros GarioudDepartment of Anesthesiology, Juliane Marie Center, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.ORCID https://orcid.org/0000-0003-1149-9946
Arash AfshariDepartment of Anesthesiology, Juliane Marie Center, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.ORCID https://orcid.org/0000-0001-5117-9715
Lau Romlund HalgreenDepartment of Clinical Biochemistry, Copenhagen University Hospital, Rigshospitalet, Glostrup, Denmark.
Kristian Østergaard NielsenGlostrup Pharmacy, Glostrup, Denmark.
Lars Peter Kloster AndersenDepartment of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.ORCID https://orcid.org/0000-0003-0053-2560

Funding

Dagmar Marshalls FondDansk Selskab for Anstesiologi og Intensiv MedicinKong Christian den Tiendes FondLægeforeningens ForskningsfondLippmann FondenOberstinde Kirsten Jensa La Cours LegatRigshospitalet
6 · The paper itself

Abstract

backgroundMelatonin may have several beneficial clinical effects in the perioperative setting. In children, it has been studied for preoperative anxiety, postoperative pain, and emergence delirium. Melatonin's pharmacokinetic profile is well-known in adults, but data in young children are sparse. We aimed to investigate the pharmacokinetic parameters of an intravenous intraoperative bolus of melatonin in pediatric surgical patients.

methodsWe enrolled 20 participants aged 1-6 years undergoing general anesthesia for elective surgery to receive an intravenous melatonin dose of 0.15 mg·kg

resultsWe included 98 samples in the pharmacokinetic analysis. We found a maximum plasma concentration (C

conclusionAdministering intravenous melatonin in a dose of 0.15 mg·kg

trial registrationCTIS: EU CT 2024-517592-20. CLINICALTRIALS: gov: NCT05541276 (registered 12/09-2022).

Indexed as

MelatoninAnesthesia, GeneralChildChild, PreschoolFemaleHalf-LifeHumansInfantInjections, IntravenousMalePediatric AnesthesiaMelatoninanxietyemergence deliriummelatoninpharmacokineticspostoperative pain

Identifiers

PMID42325096
PMCPMC13551265

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Registered trials

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