Evidence map›Paper›PMID 42325001›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2026

Choroid plexus remodeling linked to impaired CSF-mediated clearance and Alzheimer's disease progression.

Haolin Yin, Yuepeng Deng, ZiHao Lu, Yu Jiang, Chao Zuo, Jianyu Li, Linlin Guo, Binwu Ying, Giuseppe Battaglia, Xiaohe Tian and 2 more

Abstract read
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In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Haolin YinXiamen Key Lab of Psychoradiology and Neuromodulation, Department of Radiology, West China Hospital, West China Xiamen Hospital, Sichuan University, Xiamen, Fujian, China.
Yuepeng DengXiamen Key Lab of Psychoradiology and Neuromodulation, Department of Radiology, West China Hospital, West China Xiamen Hospital, Sichuan University, Xiamen, Fujian, China.
ZiHao LuXiamen Key Lab of Psychoradiology and Neuromodulation, Department of Radiology, West China Hospital, West China Xiamen Hospital, Sichuan University, Xiamen, Fujian, China.
Yu JiangXiamen Key Lab of Psychoradiology and Neuromodulation, Department of Radiology, West China Hospital, West China Xiamen Hospital, Sichuan University, Xiamen, Fujian, China.
Chao ZuoXiamen Key Lab of Psychoradiology and Neuromodulation, Department of Radiology, West China Hospital, West China Xiamen Hospital, Sichuan University, Xiamen, Fujian, China.
Jianyu LiXiamen Key Lab of Psychoradiology and Neuromodulation, Department of Radiology, West China Hospital, West China Xiamen Hospital, Sichuan University, Xiamen, Fujian, China.
Linlin GuoXiamen Key Lab of Psychoradiology and Neuromodulation, Department of Radiology, West China Hospital, West China Xiamen Hospital, Sichuan University, Xiamen, Fujian, China.
Binwu YingDepartment of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Giuseppe BattagliaXiamen Key Lab of Psychoradiology and Neuromodulation, Department of Radiology, West China Hospital, West China Xiamen Hospital, Sichuan University, Xiamen, Fujian, China.
Xiaohe TianXiamen Key Lab of Psychoradiology and Neuromodulation, Department of Radiology, West China Hospital, West China Xiamen Hospital, Sichuan University, Xiamen, Fujian, China.
Qiyong GongXiamen Key Lab of Psychoradiology and Neuromodulation, Department of Radiology, West China Hospital, West China Xiamen Hospital, Sichuan University, Xiamen, Fujian, China.
Alzheimer's Disease Neuroimaging Initiative (ADNI)

Funding

1.3.5 project for disciplines of excellence, West China Hospital, Sichuan University ZYGD230071.3.5 project for disciplines of excellence, West China Hospital, Sichuan University ZYYC24011
6 · The paper itself

Abstract

introductionImpaired cerebrospinal fluid (CSF) -mediated clearance has been implicated in Alzheimer's disease (AD), but how choroid plexus (ChP) remodeling relates to these processes in vivo remains incompletely understood.

methodsIn a large ADNI cohort, we integrated structural magnetic resonance imaging (MRI), amyloid/tau positron emission tomography (PET), and diffusion tensor imaging (DTI) -derived analysis along the perivascular space (ALPS) to characterize ChP changes and their associations with ventricular measures, glymphatic marker, CSF biomarkers, and cognition across diagnostic stages. Our experiments in APP/PS1 mice complemented human analyses.

resultsChP volume increased with disease stage, while PET signal decreased. Larger ChP volume was associated with ventricular enlargement, a lower ALPS index, higher cortical amyloid/tau burden, and worse cognitive performance. Glymphatic impairment partially mediated ChP effects on cognition and pathology. APP/PS1 mice recapitulated the key ChP and glymphatic MRI phenotypes observed in humans, alongside altered expression and localization of key proteins. DISCUSSION: ChP remodeling linked to impaired CSF-mediated clearance, highlighting its role as an early diagnostic and therapeutic target.

Indexed as

Alzheimer DiseaseChoroid PlexusAgedAged, 80 and overAmyloid beta-PeptidesAmyloid beta-Protein PrecursorAnimalsBiomarkersDiffusion Tensor ImagingDisease Models, AnimalDisease ProgressionFemaleHumansMagnetic Resonance ImagingMaleMiceAmyloid beta-PeptidesAmyloid beta-Protein PrecursorBiomarkerstau ProteinsAlzheimer diseasechoroid plexusglymphatic systemmagnetic resonance imagingpositron emission tomographypsychoradiology

Identifiers

PMID42325001
PMCPMC13284737

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.