Evidence map›Paper›PMID 42324917›Full record

Observational studyJournal of pediatric gastroenterology and nutrition2026

The relationship between nutritional management and prognosis in children on prolonged mechanical ventilation.

Chunlin Xing, Zhengzheng Zhang, Li Huang, Hong Ren, Hongjun Miao, Dong Qu, Hengmiao Gao, Yibing Cheng, Furong Zhang, Wei Xu and 6 more

Abstract readMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Journal of pediatric gastroenterology and nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Chunlin XingDepartment of Pediatric Intensive Care Unit, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Children and Adolescents' Health and Diseases, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatric Metabolism and Inflammatory Diseases, Chongqing, China.
Zhengzheng ZhangPediatric Intensive Care Unit, National Children's Medical Center, Children's Hospital of Fudan University, Shanghai, China.ORCID https://orcid.org/0000-0002-8260-9316
Li HuangDepartment of Pediatric Intensive Care Unit, National Children's Medical Center for South Central Region, Guangzhou Women and Children's Medical Center, Guangzhou, China.
Hong RenDepartment of Pediatric Intensive Care Unit, National Children's Medical Center, Shanghai Children's Medical Center, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Hongjun MiaoDepartment of Emergency/Critical Medicine, Children's Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
Dong QuDepartment of Pediatric Intensive Care Unit, Children's Hospital, Capital Institute of Pediatrics, Beijing, China.
Hengmiao GaoDepartment of Pediatric Intensive Care Unit, National Center for Children's Health, Beijing Children's hospital, Capital Medical University, Beijing, China.
Yibing ChengDepartment of Pediatric Intensive Care Unit, Children's Hospital Affiliated to Zhengzhou University, Zhengzhou, China.
Furong ZhangDepartment of Pediatric Intensive Care Unit, Wuhan Children's Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, Hubei, China.
Wei XuDepartment of Pediatric Intensive Care Unit, National Children's (Northeast) Regional Medical Center, Shengjing Hospital of China Medical University, Shenyang, China.
Pan LiuPediatric Intensive Care Unit, National Children's Medical Center, Children's Hospital of Fudan University, Shanghai, China.
Yuxin LiuPediatric Intensive Care Unit, National Children's Medical Center, Children's Hospital of Fudan University, Shanghai, China.
Lei ZhangPediatric Intensive Care Unit, Shenzhen Children's Hospital, Shenzhen, China.
Guoping LuPediatric Intensive Care Unit, National Children's Medical Center, Children's Hospital of Fudan University, Shanghai, China.
Chengjun LiuDepartment of Pediatric Intensive Care Unit, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Children and Adolescents' Health and Diseases, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatric Metabolism and Inflammatory Diseases, Chongqing, China.
Weiming ChenPediatric Intensive Care Unit, National Children's Medical Center, Children's Hospital of Fudan University, Shanghai, China.ORCID https://orcid.org/0000-0003-4868-1602

Funding

Sanming Project of Medicine in Shenzen Municipality SZSM202211034Shanghai Municipal Health System key supporting discipline projects 2023ZDFC0103The National Key Research and Development Program of China 2021YFC2701800The National Key Research and Development Program of China 2021YFC2701805
6 · The paper itself

Abstract

objectivesNutritional management is crucial for improving outcomes in children on prolonged mechanical ventilation (PMV); but detailed data are lacking. This study aimed to investigate the nutritional management of children on PMV in China and to explore their association with clinical outcomes.

methodsThis multicenter prospective observational cohort study enrolled children (aged 28 days to 18 years) who received mechanical ventilation for ≥ 21 consecutive days (PMV) from 11 tertiary hospitals across China between April 2021 and September 2022. Data on demographics and nutritional indicators (including calorie intake, protein intake, and laboratory test) were collected at enrollment (Day 1), Day 14, and Day 28. Nutritional status was assessed using Screening Tool for the Assessment of Malnutrition in Pediatrics (STAMP) screening tool and World Health Organization (WHO) age-specific Z-scores. The primary outcome was in-hospital mortality.

resultsAmong 296 children, in-hospital mortality rate was 31.8%. All were at high nutritional risk at the time of enrollment, and 51.4% were malnourished. Non-survivors received full enteral nutrition significantly less frequently than survivors at all time points (e.g., 58.5% vs. 82.2% at Day 1, p < 0.001). Linear mixed models showed non-survivors had persistently lower median caloric and protein intake (calories: 42.9 vs. 53.3 kcal/kg/day; protein: 1.2 vs. 1.6 g/kg/day; both p < 0.05). Hemoglobin levels were persistently lower in non-survivors, with no significant difference in serum albumin.

conclusionChildren on prolonged mechanical ventilation are at high nutritional risk, with total parenteral nutrition, low caloric intake and protein intake, and low hemoglobin being more pronounced in non-survivors.

Indexed as

MalnutritionRespiration, ArtificialAdolescentChildChild, PreschoolChinaEnergy IntakeEnteral NutritionFemaleHospital MortalityHumansInfantInfant, NewbornMaleNutritional StatusNutrition Assessmentenergy intakemortalitynutritional supportprolonged ventilation

Identifiers

PMID42324917
PMCPMC13539688

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.