ArticleAndrology2026
A Scalable Flow Cytometry Assay to Evaluate CatSper-mediated Ca
Article in Andrology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
5 authors.
Funding
Abstract
backgroundThe sperm-specific Ca
objectivesTo develop a scalable and multiplexed flow cytometry assay to identify compounds capable of blocking CatSper activity in mammalian sperm. MATERIALS AND
methodsThe assay relies on the stimulation of CatSper by exposing live mouse sperm to a high-K
resultsFluorescent cell barcoding greatly reduced acquisition time and reagent consumption by allowing multiple experimental conditions to be pooled and analyzed simultaneously within a single acquisition. The compound pooling strategy facilitated large-scale screening experiments. Validation confirmed that both genetic deletion and pharmacological blockade of CatSper abolish the K8.6-induced Ca
conclusionThese results establish a robust, scalable, and high-throughput screening platform for identifying novel CatSper blockers and potential male contraceptive candidates.
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