Evidence map›Paper›PMID 42324774›Full record

ArticleSmall (Weinheim an der Bergstrasse, Germany)2026

Programmable Helical Periodicity in Single-Component Supramolecular Nanofibers for Pitch-Regulated Cellular Response.

Fengli Gao, Yahong Zhou, Zheng Ling, Yajuan Peng, Sravan Baddi, Laiben Gao, Xiaxin Qiu, Xiufang Wen, Xiaoqiu Dou, Changli Zhao and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Small (Weinheim an der Bergstrasse, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Fengli GaoState Key Lab of Metal Matrix Composites, Shanghai Key Laboratory for Molecular Engineering of Chiral Drug, School of Materials Science and Engineering, Shanghai Jiao Tong University, Shanghai, China.
Yahong ZhouKey Laboratory of Bio-inspired Materials and Interfacial Science, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing, China.ORCID 0000-0002-2482-1976
Zheng LingZhengzhou Industrial Technology Research Institute of Shanghai Jiao Tong University, Zhengzhou, China.
Yajuan PengSchool of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou, China.
Sravan BaddiState Key Lab of Metal Matrix Composites, Shanghai Key Laboratory for Molecular Engineering of Chiral Drug, School of Materials Science and Engineering, Shanghai Jiao Tong University, Shanghai, China.
Laiben GaoState Key Lab of Metal Matrix Composites, Shanghai Key Laboratory for Molecular Engineering of Chiral Drug, School of Materials Science and Engineering, Shanghai Jiao Tong University, Shanghai, China.
Xiaxin QiuState Key Lab of Metal Matrix Composites, Shanghai Key Laboratory for Molecular Engineering of Chiral Drug, School of Materials Science and Engineering, Shanghai Jiao Tong University, Shanghai, China.
Xiufang WenSchool of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou, China.ORCID 0000-0001-5071-8940
Xiaoqiu DouState Key Lab of Metal Matrix Composites, Shanghai Key Laboratory for Molecular Engineering of Chiral Drug, School of Materials Science and Engineering, Shanghai Jiao Tong University, Shanghai, China.
Changli ZhaoState Key Lab of Metal Matrix Composites, Shanghai Key Laboratory for Molecular Engineering of Chiral Drug, School of Materials Science and Engineering, Shanghai Jiao Tong University, Shanghai, China.
Chuanliang FengState Key Lab of Metal Matrix Composites, Shanghai Key Laboratory for Molecular Engineering of Chiral Drug, School of Materials Science and Engineering, Shanghai Jiao Tong University, Shanghai, China.ORCID 0000-0001-6137-5568

Funding

National Key Research and Development Program 2024YFB3814600National Natural Science Foundation of China 52403161National Natural Science Foundation of China NSFC 52533014Science and Technology Commission of Shanghai Municipality 20S31904600Science and Technology Commission of Shanghai Municipality 25CL2900600Shanghai Jiao Tong University "Star Project" of Biomedical Multi-discipline Research Program YG2024ZD13Shanghai Pujiang Program 20PJ1407400SJTU Trans-med Awards Research WF5401X62X603
6 · The paper itself

Abstract

Supramolecular chiral architectures with tunable helical periodicity are essential for mimicking biological complexity and understanding chiral evolution in nature. However, achieving a continuous range of helical pitches, remains a formidable challenge, as conventional methods typically rely on complex multicomponent systems that suffer from chemical heterogeneity and limited predictability. Here, we report that single-component camptothecin (CPT) spontaneously assembles into homochiral nanofibers with a widely programmable and predictable helical pitch that can be precisely controlled by adjusting the monomer concentration. Such regulatable helical pitches arise from the planar, rigid π-conjugated backbone of CPT, affording precise modulation of intermolecular π-π interactions. We then elucidate a hierarchical assembly mechanism transitioning from microaggregates to twisted helical nanofibers, enabling an intense dissymmetry factor (g

Indexed as

NanofibersAnimalsCamptothecinCell AdhesionCamptothecincell adhesionchiralityhelical pitchsupramolecular nanofibers

Identifiers

PMID42324774
PMCPMC13450303

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.