Evidence map›Paper›PMID 42324649›Full record

ArticleMagnetic resonance in medicine2026

Real-Time Monitoring of Tissue Oxygenation During Hyperbaric Oxygen Exposure Using In Vivo EPR Oximetry.

Maciej M Kmiec, Sergey V Petryakov, Alireza Kheirollah, Conner S Ubert, Ryan C O'Connell, Periannan Kuppusamy

Abstract read
In one paragraph

Article in Magnetic resonance in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Maciej M KmiecDepartment of Radiology, Geisel School of Medicine, Dartmouth College, Hanover, New Hampshire, USA.
Sergey V PetryakovDepartment of Radiology, Geisel School of Medicine, Dartmouth College, Hanover, New Hampshire, USA.
Alireza KheirollahDepartment of Surgery, Geisel School of Medicine, Dartmouth College, Hanover, New Hampshire, USA.
Conner S UbertDepartment of Radiology, Geisel School of Medicine, Dartmouth College, Hanover, New Hampshire, USA.
Ryan C O'ConnellDepartment of Radiology, Geisel School of Medicine, Dartmouth College, Hanover, New Hampshire, USA.
Periannan KuppusamyDepartment of Radiology, Geisel School of Medicine, Dartmouth College, Hanover, New Hampshire, USA.

Funding

Probes and Methods for Clinical OximetryR01EB004031 · NIBIB · OHIO STATE UNIVERSITY · PI KUPPUSAMY, PERIANNAN · 2004 to 2021
$7.1M
Multimodal Marker for imaging oximetry in radiotherapyR01CA269234 · NCI · DARTMOUTH COLLEGE · PI PERIANNAN KUPPUSAMY · 2023 to 2026
$3.0M
Novel oxygen monitoring system for on-site use in the clinicR01EB036124 · NIBIB · DARTMOUTH COLLEGE · PI PERIANNAN KUPPUSAMY · 2024 to 2026
$949k
NCI NIH HHS R01 CA269234NIBIB NIH HHS R01 EB004031NIBIB NIH HHS R01 EB036124NIH HHS R01 EB004031NIH HHS R01 EB036124
6 · The paper itself

Abstract

purposeHyperbaric oxygen (HBO) therapy increases blood oxygen levels by exposing patients to 100% oxygen under elevated pressure and is used clinically for conditions such as decompression sickness, carbon monoxide poisoning, chronic wounds, and impaired tissue healing. However, real-time precise and quantitative measurement of tissue oxygen tension (pO

methodsWe developed a specialized small-animal hyperbaric chamber compatible with in vivo electron paramagnetic resonance (EPR) oximetry using customized OxyTrack oxygen detectors. Up to two detectors were implanted simultaneously to measure pO

resultsThe chamber operated safely and stably up to 2 ATA, enabling continuous real-time pO

conclusionThe small-animal HBO chamber enables real-time, tissue-specific assessment of oxygen dynamics under clinically relevant hyperbaric conditions. The approach could facilitate optimization of HBO protocols and support translational investigation of oxygen-modulated therapies, including radiation and drug responses in solid tumors.

Indexed as

Hyperbaric OxygenationMuscle, SkeletalOximetryOxygenOxygen SaturationAnimalsComputer SystemsDiving and Hyperbaric MedicineElectron Spin Resonance SpectroscopyEquipment DesignEquipment Failure AnalysisMiceMice, Inbred C57BLOxygenEPR oximetryHBO chamberhyperoxygenationOxyTracktumor

Identifiers

PMID42324649
PMCPMC13419272

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.