Evidence map›Paper›PMID 42324605›Full record

ArticleThe New phytologist2026

MtGRF8 interacts with MtSymCRK and prevents early bacteroid death during Medicago - Sinorhizobium symbiosis.

Chaoyan Yin, Kévin Magne, Fathi Berrabah, Dario Monachello, Gautier Bernal, Kirankumar S Mysore, Jiangqi Wen, Catherine Etchebest, Pascal Ratet, Véronique Gruber

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The New phytologist, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Chaoyan Yin *Université Paris-Saclay, CNRS, INRAE, Université Evry, Institute of Plant Sciences Paris-Saclay (IPS2), Gif sur Yvette, 91190, France.ORCID https://orcid.org/0000-0003-4905-2867
Kévin Magne *Université Paris-Saclay, CNRS, INRAE, Université Evry, Institute of Plant Sciences Paris-Saclay (IPS2), Gif sur Yvette, 91190, France.ORCID https://orcid.org/0000-0002-6779-5683
Fathi BerrabahDepartment of Biology, Faculty of Sciences, Amar Telidji University, Laghouat, 03000, Algeria.ORCID https://orcid.org/0000-0002-5710-8421
Dario MonachelloUniversité Paris-Saclay, CNRS, INRAE, Université Evry, Institute of Plant Sciences Paris-Saclay (IPS2), Gif sur Yvette, 91190, France.ORCID https://orcid.org/0000-0001-7551-0214
Gautier BernalUniversité Paris-Saclay, CNRS, INRAE, Université Evry, Institute of Plant Sciences Paris-Saclay (IPS2), Gif sur Yvette, 91190, France.ORCID https://orcid.org/0000-0002-2253-6397
Kirankumar S MysoreThe Institute of Agricultural Biosciences, Oklahoma State University, Ardmore, OK, 73401, USA.ORCID https://orcid.org/0000-0002-9805-5741
Jiangqi WenThe Institute of Agricultural Biosciences, Oklahoma State University, Ardmore, OK, 73401, USA.ORCID https://orcid.org/0000-0001-5113-7750
Catherine EtchebestUniversité Paris Cité and Université de la Réunion, INSERM, EFS, BIGR U1134, DSIMB Bioinformatics team, Paris, F-75015, France.ORCID https://orcid.org/0000-0002-5871-2372
Pascal RatetUniversité Paris-Saclay, CNRS, INRAE, Université Evry, Institute of Plant Sciences Paris-Saclay (IPS2), Gif sur Yvette, 91190, France.ORCID https://orcid.org/0000-0002-8621-1495
Véronique GruberUniversité Paris-Saclay, CNRS, INRAE, Université Evry, Institute of Plant Sciences Paris-Saclay (IPS2), Gif sur Yvette, 91190, France.ORCID https://orcid.org/0000-0002-4877-1803

Funding

Agence Nationale de la Recherche ANR-11-IDEX-0003-02China Scholarship Council PhD Scholarship 202008410235IdEX Universite de Paris ANR-18-IDEX-0001LabEx Saclay Plant Sciences ANR-10-LABX-0040-SPSLabEx Saclay Plant Sciences ANR-17-EUR-0007LabEx Saclay Plant Sciences EUR SPS-GSRNational Science Foundation DBI0703285National Science Foundation IOS-1127155
6 · The paper itself

Abstract

In Medicago littoralis R-108, Symbiotic CYSTEINE-RICH RECEPTOR-LIKE KINASE (MtSymCRK) is required to prevent defense reactions in symbiotic nodules during chronic infection. MtSymCRK represents a key legume symbiotic gene controlling nodule immunity and early bacteroid survival, but its mode of action in the cell signaling remains poorly understood. This study investigated proteins interacting with MtSymCRK by screening an Arabidopsis thaliana open reading frame (ORF) library using yeast-two-hybrid followed by translational genetics towards R-108. Finally, we conducted a reverse genetic approach in R-108 using Transposon of Nicotiana tabacum 1 (Tnt1) insertional mutants. We identified a 14-3-3 protein, AtGENERAL REGULATORY FACTOR 8 (AtGRF8) interacting with MtSymCRK kinase domain (MtSymCRK

Indexed as

MedicagoPlant ProteinsSinorhizobiumSymbiosis14-3-3 ProteinsArabidopsisGene Expression Regulation, PlantMutationNicotianaProtein BindingRoot Nodules, Plant14-3-3 ProteinsPlant Proteins14‐3‐3bacteroid persistenceMedicago littoralisMtGRF8MtSymCRKnodule immunitynodule senescenceroot nodule symbiosis

Identifiers

PMID42324605
PMCPMC13443349

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.