ArticleJournal of biomedical materials research. Part B, Applied biomaterials2026
Strut Thickness and Species-Specific Healing Are Key Considerations in Developing Zinc-Based Biodegradable Arterial Stents.
Lea M Morath, Shebeer A Rahim, Cole A Baker, Shobana Santhanam, Deirdre E J Anderson, Alex M LaMere, Lindy G Oujiri, Greet Kerckhofs, Grzegorz Pyka, Monica T Hinds and 3 more
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In one paragraphArticle in Journal of biomedical materials research. Part B, Applied biomaterials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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2 · The registryThe trial behind it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
13 authors.
Lea M MorathDepartment of Biomedical Engineering, Michigan Technological University, Houghton, Michigan, USA.
Shebeer A RahimDepartment of Materials Science and Engineering, Michigan Technological University, Houghton, Michigan, USA.
Cole A BakerDepartment of Biomedical Engineering, Oregon Health and Science University, Portland, Oregon, USA.
Shobana SanthanamDepartment of Biomedical Engineering, Oregon Health and Science University, Portland, Oregon, USA.
Deirdre E J AndersonDepartment of Biomedical Engineering, Oregon Health and Science University, Portland, Oregon, USA.ORCID 0000-0002-2853-2821 Alex M LaMereDepartment of Biomedical Engineering, Michigan Technological University, Houghton, Michigan, USA.
Lindy G OujiriDepartment of Biomedical Engineering, Michigan Technological University, Houghton, Michigan, USA.
Grzegorz PykaBiomechanics Lab, Institute of Mechanics, Materials and Civil Engineering, UCLouvain, Louvain-la-Neuve, Belgium.
Monica T HindsDepartment of Biomedical Engineering, Oregon Health and Science University, Portland, Oregon, USA.ORCID 0000-0002-5267-3376 Shu Q LiuDepartment of Biomedical Engineering, Northwestern University, Evanston, Illinois, USA.
Jaroslaw W DrelichDepartment of Materials Science and Engineering, Michigan Technological University, Houghton, Michigan, USA.
Jeremy GoldmanDepartment of Biomedical Engineering, Michigan Technological University, Houghton, Michigan, USA.ORCID 0000-0002-5851-3330 Funding
Upgrade of confocal microscopy at the Oregon National Primate Research CenterP51OD011092 · OD · OREGON HEALTH & SCIENCE UNIVERSITY · PI Bonnie J. Nagel · 2012 to 2026
$203.9MContact Pathway Activation on Vascular DevicesR01HL144113 · NHLBI · OREGON HEALTH & SCIENCE UNIVERSITY · PI HINDS, MONICA T, MCCARTY, OWEN J · 2018 to 2025
$6.0MBiodegradable Metal Stent Alloys for Vascular ApplicationsR01HL168696 · NHLBI · OREGON HEALTH & SCIENCE UNIVERSITY · PI Jeremy Goldman, Monica T Hinds · 2023 to 2026
$2.8MPatient-specific blood cell reactivity and flow dynamic profiles in transcatheter aortic valve replacementR01HL167442 · NHLBI · OREGON HEALTH & SCIENCE UNIVERSITY · PI Joseph E Aslan, Lakshmi Prasad Dasi · 2024 to 2026
$2.0MNovel Bioresorbable Vascular Scaffolds with Uniform BiodegradationR56HL163552 · NHLBI · MICHIGAN TECHNOLOGICAL UNIVERSITY · PI DRELICH, JAROSLAW W · 2023 to 2023
$462kNHLBI NIH HHS R01 HL144113NHLBI NIH HHS R01 HL167442NHLBI NIH HHS R01 HL168696NHLBI NIH HHS R56 HL163552NIH HHS P51 OD011092Oregon National Primate Research Center P51OD011092US National Institute of Health-National Heart, Lung, and Blood Institute R01HL144113US National Institute of Health-National Heart, Lung, and Blood Institute R01HL167442US National Institute of Health-National Heart, Lung, and Blood Institute R01HL168696US National Institute of Health-National Heart, Lung, and Blood Institute R56HL163552
6 · The paper itselfAbstract
Zinc-based biodegradable stents offer a promising solution for temporary vascular support, aiding in vessel healing while reducing long-term complications such as thrombosis and restenosis. This study examined three zinc-based alloys: AMZ (Zn-4.0Ag-0.6Mn-0.1Zr), ACMZ (Zn-3.5Ag-0.5Cu-0.7Mn-0.1Zr), and CMM (Zn-1.0Cu-0.6Mn-0.05 Mg), all featuring reduced wire diameters of 0.12 mm. The focus was on their microstructure, mechanical performance, thrombogenicity, and in vivo biocompatibility. The alloys were processed through cold drawing and heat treatment, resulting in ultra-fine-grained structures measuring less than 1 μm. Energy dispersive spectroscopy (EDS) and x-ray diffraction (XRD) analyses confirmed the presence of strengthening intermetallic phases (AgZn
Indexed as
Absorbable ImplantsAlloysMaterials TestingStentsZincAnimalsMaleMiceRatsRats, Sprague-DawleyAlloysZincarterial stentsbiodegradable metalscorrosionintimal hyperplasiamechanical performancethrombosis
Identifiers
PMID42324591
PMCPMC13383813
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