Evidence map›Paper›PMID 42324587›Full record

ArticleActa neuropathologica communications2026

PCK2 as a potential therapeutic target for aggressive MYC-amplified non-WNT/non-SHH medulloblastoma based on tumor continuum.

Shuaishuai Xue, Zhengming Zhan, Yonghua Cai, Wei Chen, Ruizhe Chen, Yangqi Mao, Cheng Xie, Jun Liu, Ziyi Luo, Siyuan Liu and 4 more

Abstract read
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In one paragraph

Article in Acta neuropathologica communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

14 authors.

Shuaishuai XueDepartment of Neurosurgery, Nanfang Hospital, Southern Medical University, Guangzhou north road 1838, Guangzhou, 510515, Guangdong Provincial, China.
Zhengming ZhanDepartment of Neurosurgery, Nanfang Hospital, Southern Medical University, Guangzhou north road 1838, Guangzhou, 510515, Guangdong Provincial, China.
Yonghua CaiDepartment of Neurosurgery, Nanfang Hospital, Southern Medical University, Guangzhou north road 1838, Guangzhou, 510515, Guangdong Provincial, China.
Wei ChenDepartment of Neurosurgery, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangdong Provincial Clinical Research Center for Child Health, Guangzhou, 510623, China.
Ruizhe ChenDepartment of Neurosurgery, Nanfang Hospital, Southern Medical University, Guangzhou north road 1838, Guangzhou, 510515, Guangdong Provincial, China.
Yangqi MaoDepartment of Neurosurgery, Nanfang Hospital, Southern Medical University, Guangzhou north road 1838, Guangzhou, 510515, Guangdong Provincial, China.
Cheng XieDepartment of Neurology, Ganzhou People's Hospital, Ganzhou Hospital-Nanfang Hospital, Southern Medical University, Ganzhou, 341000, Jiangxi, China.
Jun LiuDepartment of Neurosurgery, The 2nd Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, 330000, Jiangxi, China.
Ziyi LuoDepartment of Neurosurgery, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangdong Provincial Clinical Research Center for Child Health, Guangzhou, 510623, China.
Siyuan LiuDepartment of Otorhinolaryngology Head and Neck Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
Xian ZhangDepartment of Neurosurgery, Nanfang Hospital, Southern Medical University, Guangzhou north road 1838, Guangzhou, 510515, Guangdong Provincial, China.
Peng LiDepartment of Neurosurgery, Nanfang Hospital, Southern Medical University, Guangzhou north road 1838, Guangzhou, 510515, Guangdong Provincial, China. zhimeng_li@163.com.
Hao LongDepartment of Neurosurgery, Nanfang Hospital, Southern Medical University, Guangzhou north road 1838, Guangzhou, 510515, Guangdong Provincial, China. longh812@163.com.
Ye SongDepartment of Neurosurgery, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangdong Provincial Clinical Research Center for Child Health, Guangzhou, 510623, China. songye0724@126.com.

Funding

Guangdong Medical Research Foundation 2023A1515010633Guangdong Medical Research Foundation 2023A1515012382National Nature Science Fund of China 82272879
6 · The paper itself

Abstract

Medulloblastoma, the most common malignant pediatric posterior fossa tumor, exhibits metabolic reprogramming and tumor immune microenvironment heterogeneity in non-WNT/non-SHH subgroups, yet the interplay between these features remains poorly defined. Revealing potential molecular features and hidden therapeutic target, we integrated the transcriptomic data of non-WNT/non-SHH medulloblastoma from GEO and EMBL-EBI databases. Through examination of the Grp3/4 transcriptional continuum, we identified PCK2 (a key gene in the TCA cycle with the highest correlation with continuum score). We validated PCK2 as a driver of proliferation, migration, invasion, glycolysis, and M2 macrophage polarization in MYC-amplified MB cells through short hairpin RNA knockdown experiments. Together, our findings establish metabolic-TIME crosstalk as a prognostic determinant and proffer PCK2 as a therapeutic target for aggressive MB subtypes, offering insights into metabolic subtyping and precision therapy strategies to improve clinical outcomes.

Indexed as

Cerebellar NeoplasmsMedulloblastomaCell Line, TumorCell MovementCell ProliferationGene Expression Regulation, NeoplasticHumansMetabolic ReprogrammingProto-Oncogene Proteins c-mycTumor MicroenvironmentMYC protein, humanProto-Oncogene Proteins c-mycImmune MicroenvironmentMedulloblastomaMetabolismnon-WNT/non-SHHPCK2

Identifiers

PMID42324587
PMCPMC13531781

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