ArticleChinese medicine2026
Panax quinquefolium saponin decreases atherosclerosis in ovariectomized ApoE
Article in Chinese medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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10 authors.
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Abstract
backgroundPostmenopausal women are at an increased risk for atherogenesis. Panax quinquefolium saponin (PQS) has demonstrated beneficial effects on decreasing inflammatory response, alleviating oxidative stress and improving endothelial function. However, the effect of PQS on atherogenesis in postmenopausal women remains unknown. This study explored the effects of PQS on different pathological stages (8 or 14 weeks) of atherogenesis in ApoE
methodsAtherosclerotic plaque, levels of serum inflammatory cytokines and apoptosis of aortic endothelium were detected. Human umbilical vein endothelial cells (HUVECs) treated with oxidized low-density lipoprotein (ox-LDL) were used to investigate the mechanism. Using network pharmacology, molecular docking and receptor inhibitor to explore the target of PQS in ovariectomized ApoE
resultsApoE
conclusionsThe study indicated that PQS decreased atherosclerotic plaque by reducing inflammation and apoptosis of aortic endothelium in ovariectomized ApoE
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