Evidence map›Paper›PMID 42324577›Full record

ArticleZoonoses and public health2026

Serological and Molecular Surveillance of Influenza A Virus in Dogs and Cats in Central Chile.

Cecilia Baumberger, Francisca Di Pillo, Fernanda Sanchez, Alejandra Sepúlveda, Victor Marambio, Katherinne Orozco, David Tapia, Christopher Hamilton-West, Bridgett Sharp, Stacey Schultz-Cherry and 1 more

Abstract read
In one paragraph

Article in Zoonoses and public health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Cecilia BaumbergerDepartamento de Medicina Preventiva, Facultad de Ciencias Veterinarias y Pecuarias, Universidad de Chile, Santiago, Chile.
Francisca Di PilloNúcleo de Investigación en One Health, Facultad de Medicina Veterinaria y Agronomía, Universidad de Las Américas, Santiago, Chile.ORCID https://orcid.org/0000-0001-6662-0323
Fernanda SanchezPrograma de Doctorado en Medicina de la Conservación, Facultad de Ciencias de la Vida, Universidad Andrés Bello, Santiago, Chile.
Alejandra SepúlvedaDepartamento de Medicina Preventiva, Facultad de Ciencias Veterinarias y Pecuarias, Universidad de Chile, Santiago, Chile.
Victor MarambioDepartamento de Medicina Preventiva, Facultad de Ciencias Veterinarias y Pecuarias, Universidad de Chile, Santiago, Chile.ORCID https://orcid.org/0000-0001-8633-8317
Katherinne OrozcoDepartamento de Medicina Preventiva, Facultad de Ciencias Veterinarias y Pecuarias, Universidad de Chile, Santiago, Chile.
David TapiaDepartamento de Medicina Preventiva, Facultad de Ciencias Veterinarias y Pecuarias, Universidad de Chile, Santiago, Chile.ORCID https://orcid.org/0000-0002-9601-5471
Christopher Hamilton-WestDepartamento de Medicina Preventiva, Facultad de Ciencias Veterinarias y Pecuarias, Universidad de Chile, Santiago, Chile.ORCID https://orcid.org/0000-0002-5609-2237
Bridgett SharpDepartment of Infectious Diseases, St. Jude Children's Hospital, Memphis, Tennessee, USA.
Stacey Schultz-CherryDepartment of Infectious Diseases, St. Jude Children's Hospital, Memphis, Tennessee, USA.
Pedro Jiménez-BluhmSurveillance, Epidemiology, and New Technologies for Infectious Emerging Threats (SENTINET), Santiago, Chile.ORCID https://orcid.org/0000-0002-6474-0804

Funding

NIAID Centers of Excellence for Influenza Research and Response: Universal Influenza Vaccine Research Activities75N93021C00016 · NIAID · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI WEBBY, RICHARD · 2021 to 2025
$91.4M
Agencia Nacional de Investigación y Desarrollo CIN250062Fondo Nacional de Desarrollo Científico y Tecnológico 1241662Fondo Nacional de Desarrollo Científico y Tecnológico 1241908Fondo Nacional de Desarrollo Científico y Tecnológico 3260453National Institute of Allergy and Infectious Diseases CEIRR 75N93021C00016NIH HHS 75N93021C00016
6 · The paper itself

Abstract

introductionInfluenza A virus (IAV) is a zoonotic pathogen with pandemic potential that infects a wide range of species, including companion animals. Although surveillance efforts have primarily focused on North America, Europe and Asia, data from South America remain scarce. This study evaluated the molecular and serological evidence of IAV circulation in dogs and cats from shelters and multi-pet households in central Chile.

methodsBetween June and November 2020, oropharyngeal swabs and serum samples were collected from dogs and cats in shelters and multi-pet households in central Chile. Samples were analysed by RT-qPCR, NP-ELISA and hemagglutination inhibition assay.

resultsIAV was detected by RT-qPCR in 3.2% (11/342) of dogs (95% CI: 1.3%-5.1%) and 5.8% (4/69) of cats (95% CI: 0.3%-11.3%). Serological analysis revealed IAV seropositivity in 55.5% (96/173) of dogs (95% CI: 48.1%-62.9%) and 50.0% (10/20) of cats (95% CI: 28.1%-71.9%). Additionally, pdmH1N1 antibodies were detected in 26 animals (25.7%; 95% CI: 17.2%-34.2%) out of 101 NP-ELISA-positive serum samples, with higher median titres for cats (median = 160) compared to dogs (median = 20). Low-level antibody titres against Canine/H3N2 (range = 10-20) were identified in three dogs (3.0%; 95% CI: 0.0%-6.3%), whereas no antibodies were detected against Canine/H3N8 or Avian/H3N6. No significant associations were observed between seropositivity and animal age, sex, origin or area.

conclusionsThis study presents the first report of IAV detection in cats in South America and highlights a high level of IAV exposure among companion animals in central Chile. These findings underscore the importance of including pets in IAV surveillance efforts under a One Health approach and highlight the need for expanded monitoring and genetic characterization of circulating strains to assess zoonotic risk.

Indexed as

Cat DiseasesDog DiseasesInfluenza A virusOrthomyxoviridae InfectionsAnimalsAntibodies, ViralCatsChileDogsFemaleSeroepidemiologic StudiesAntibodies, Viralcatscompanion animalsdogshemagglutination inhibitioninfluenza A virusRT‐qPCR

Identifiers

PMID42324577
PMCPMC13535724

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.