Trial reportBMC pregnancy and childbirth2026
Norepinephrine versus colloid for preventing spinal anesthesia-induced hypotension and its impact on intracranial pressure in preeclamptic parturients: a randomized double-blind controlled trial.
Trial report in BMC pregnancy and childbirth, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
objectiveThis study aims to evaluate the effects of two strategies for preventing hypotension after spinal anesthesia (prophylactic fluid loading and norepinephrine infusion) on intracranial pressure (ICP) in preeclamptic women by measuring the optic nerve sheath diameter (ONSD) using ultrasound.
methodsIn this prospective, randomized, controlled trial, 60 healthy parturients and 60 preeclamptic parturients undergoing cesarean delivery under spinal anesthesia were enrolled. Normal parturients were randomly assigned to the infusion group (NA group, n = 30) and NE (norepinephrine) group (NB group, n = 30), while preeclamptic parturients were randomly assigned to the infusion group (PA group, n = 30) and NE group (PB group, n = 30). The primary outcome was bilateral ONSD values at baseline, pretreatment, 5 min after spinal anesthesia (Post-SA), and 5 min after fetal delivery (Post-birth). The secondary outcomes included maternal general characteristics, renal function indices, postoperative headache, fetal umbilical cord arterial blood gas indices, and Apgar scores.
resultsPretreatment ONSD was significantly higher than baseline in both infusion groups, and baseline ONSD was higher in preeclamptic versus normal parturients (all P < 0.01). Among preeclamptic parturients, pretreatment ONSD was higher in the PA group than in the PB group (P < 0.01), with a similar difference (PA > PB) confirmed in normal parturients (P < 0.01). In addition, compared to the PA group, the PB group showed no significant differences in systolic blood pressure (SBP), diastolic blood pressure (DBP), or mean arterial pressure (MAP) at any time point in preeclamptic parturients (P > 0.05). Conversely, in normal parturients, post-birth SBP, DBP, and MAP were significantly higher in the NB than in the NA group (P < 0.01). Baseline hemodynamic values were higher in preeclamptic versus normal parturients (P < 0.01), and post-birth values decreased significantly from baseline in the PA and PB groups (P < 0.001). No significant intergroup differences were observed in maternal heart rate (HR), renal function indices, umbilical artery blood gas indices, Apgar scores, or the incidence of postpartum headache (all P > 0.05).
conclusionFor preeclamptic parturients, the risks induced by ICP increase should be noted. Compared to colloids, prophylactic infusion of NE was more effective and safer and did not increase ICP.
trial registrationThis randomized controlled trial was registered on Chinese Clinical Trial Registry (ChiCTR2400092317; http://www.chictr.org.cn/ ) with the Clinical Trial Registry ({1}).
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.