Evidence map›Paper›PMID 42324382›Full record

ArticleOncogene2026

HSP47 is a potential dual cell target and prognostic factor in pancreatic cancer.

George Sharbeen, Estrella Gonzales-Aloy, Janet Youkhana, John Kokkinos, Rosa Mistica C Ignacio, Joshua A McCarroll, Aparna S Raina, Chantal Kopecky, Jie Liu, Amanda Mawson and 19 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncogene, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

29 authors.

George Sharbeen *Pancreatic Cancer Translational Research Group, School of Biomedical Sciences, Lowy Cancer Research Centre, UNSW Sydney, Sydney, NSW, Australia. g.sharbeen@unsw.edu.au.ORCID http://orcid.org/0000-0002-6373-1930
Estrella Gonzales-Aloy *Pancreatic Cancer Translational Research Group, School of Biomedical Sciences, Lowy Cancer Research Centre, UNSW Sydney, Sydney, NSW, Australia.
Janet Youkhana *Pancreatic Cancer Translational Research Group, School of Biomedical Sciences, Lowy Cancer Research Centre, UNSW Sydney, Sydney, NSW, Australia.
John KokkinosPancreatic Cancer Translational Research Group, School of Biomedical Sciences, Lowy Cancer Research Centre, UNSW Sydney, Sydney, NSW, Australia.
Rosa Mistica C IgnacioPancreatic Cancer Translational Research Group, School of Biomedical Sciences, Lowy Cancer Research Centre, UNSW Sydney, Sydney, NSW, Australia.
Joshua A McCarrollAustralian Centre for Nanomedicine, UNSW Sydney, Sydney, NSW, Australia.
Aparna S RainaPancreatic Cancer Translational Research Group, School of Biomedical Sciences, Lowy Cancer Research Centre, UNSW Sydney, Sydney, NSW, Australia.
Chantal KopeckyPancreatic Cancer Translational Research Group, School of Biomedical Sciences, Lowy Cancer Research Centre, UNSW Sydney, Sydney, NSW, Australia.
Jie LiuPancreatic Cancer Translational Research Group, School of Biomedical Sciences, Lowy Cancer Research Centre, UNSW Sydney, Sydney, NSW, Australia.
Amanda MawsonPancreatic Cancer Translational Research Group, School of Biomedical Sciences, Lowy Cancer Research Centre, UNSW Sydney, Sydney, NSW, Australia.
Andrea NunezPancreatic Cancer Translational Research Group, School of Biomedical Sciences, Lowy Cancer Research Centre, UNSW Sydney, Sydney, NSW, Australia.
Cyrille BoyerAustralian Centre for Nanomedicine, UNSW Sydney, Sydney, NSW, Australia.
Mert ErkanMehmet Ali Aydinlar Acibadem University, Department of General Surgery; Ataşehir Hospital, Istanbul, Turkey.
David GoldsteinSchool of Clinical Medicine, UNSW Sydney, Prince of Wales Hospital, Sydney, NSW, Australia.ORCID http://orcid.org/0000-0001-6142-3291
Koroush S HaghighiSchool of Clinical Medicine, UNSW Sydney, Prince of Wales Hospital, Sydney, NSW, Australia.
Paul TimpsonTumour Ecosystems Program, The Garvan Institute of Medical Research and the Kinghorn Cancer Centre, Sydney, NSW, Australia.ORCID http://orcid.org/0000-0002-5514-7080
Sean C WarrenTumour Ecosystems Program, The Garvan Institute of Medical Research and the Kinghorn Cancer Centre, Sydney, NSW, Australia.
Kendelle J MurphyTumour Ecosystems Program, The Garvan Institute of Medical Research and the Kinghorn Cancer Centre, Sydney, NSW, Australia.
Anthony J GillThe Garvan Institute of Medical Research and the Kinghorn Cancer Centre, Sydney, NSW, Australia.ORCID http://orcid.org/0000-0002-9447-1967
Amber L JohnsAustralian Pancreatic Cancer Genome Initiative (APGI), Sydney, NSW, Australia.
Angela ChouThe Garvan Institute of Medical Research and the Kinghorn Cancer Centre, Sydney, NSW, Australia.
Australian Pancreatic Cancer Genome Initiative (APGI)
Elvis PandzicKatharina Gaus Light Microscopy Facility, Mark Wainwright Analytical Centre, Lowy Cancer Research Centre, UNSW Sydney, Sydney, NSW, Australia.
Sandra FokKatharina Gaus Light Microscopy Facility, Mark Wainwright Analytical Centre, Lowy Cancer Research Centre, UNSW Sydney, Sydney, NSW, Australia.
Renee WhanKatharina Gaus Light Microscopy Facility, Mark Wainwright Analytical Centre, Lowy Cancer Research Centre, UNSW Sydney, Sydney, NSW, Australia.
Val GebskiNHMRC Clinical Trials Centre, University of Sydney, Sydney, NSW, Australia.
Jennifer P MortonSchool of Cancer Sciences, University of Glasgow, Glasgow UK and CRUK Scotland Institute, Glasgow, UK.ORCID http://orcid.org/0000-0001-5766-9141
Minoti AptePancreatic Research Group, South Western Sydney Clinical Campuses, School of Clinical Medicine, UNSW and Ingham Institute for Applied Medical Research, Sydney, NSW, Australia.
Phoebe A PhillipsPancreatic Cancer Translational Research Group, School of Biomedical Sciences, Lowy Cancer Research Centre, UNSW Sydney, Sydney, NSW, Australia. p.phillips@unsw.edu.au.

Funding

Cancer Institute NSW (Cancer Institute New South Wales) CDF181166
6 · The paper itself

Abstract

Pancreatic ductal adenocarcinoma (PDAC) is a deadly disease with a dismal 5-year survival rate at 12%. The fibrotic PDAC desmoplasia is a major contributor to chemoresistance and metastasis that drive this poor prognosis. Cancer-associated fibroblasts (CAFs) generate PDAC tumour fibrosis and have been identified as therapeutic targets to remodel the stroma to a more drug-permissive microenvironment. We assessed the therapeutic potential of inhibiting the collagen chaperone, heat shock protein 47 (HSP47) in PDAC cells and CAFs. Collagen is a key component of PDAC fibrosis and requires the activity of HSP47 to ensure correct maturation and secretion. Herein, we show that HSP47 knockdown inhibits both PDAC cells and CAF proliferation in vitro. In vivo, therapeutic HSP47 knockdown in orthotopic PDAC tumours significantly reduced intratumoural fibrosis and opened intratumoural blood vessels, while stable HSP47 knockdown specifically in CAFs additionally reduced PDAC tumour growth. We observed that HSP47 is highly expressed in the stroma of >80% of patients in a PDAC cohort (Australian Pancreatic Cancer Genome Initiative), but that it was only prognostic of poorer overall survival in the tumour compartment. Functional relevance in the tumour compartment was further validated in 3D human PDAC explants. Our work demonstrates that HSP47 is a potential therapeutic target in both PDAC cells and CAFs and represents a robust target to interfere with tumour collagen deposition.

Indexed as

Carcinoma, Pancreatic DuctalHSP47 Heat-Shock ProteinsPancreatic NeoplasmsAnimalsCancer-Associated FibroblastsCell Line, TumorCell ProliferationFemaleGene Knockdown TechniquesHumansMicePrognosisTumor MicroenvironmentHSP47 Heat-Shock ProteinsSERPINH1 protein, human

Identifiers

PMID42324382
PMCPMC13407167

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.