Evidence map›Paper›PMID 42324291›Full record

ArticleScientific reports2026

High-gamma frequency-tagged magnetoencephalography reveals time-resolved task-related functional coupling during spatial cognition.

Kenji Yoshiki, Masashi Kinoshita, Ruochu Xiong, Yoshihiro Misaka, Kiwamu Kudo, Eiichi Okumura, Hirofumi Morise, Riho Nakajima, Mitsutoshi Nakada

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In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Kenji YoshikiDepartment of Neurosurgery, Division of Medicine, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Ishikawa, Japan.
Masashi KinoshitaDepartment of Neurosurgery, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, 13 - 1 Takara-machi, Kanazawa, Ishikawa, 920-8641, Japan. m-kinoshita@med.kanazawa-u.ac.jp.ORCID 0000-0002-2148-8231
Ruochu XiongDepartment of Neurosurgery, Division of Medicine, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Ishikawa, Japan.
Yoshihiro MisakaMedical Imaging Business Center, Ricoh Company, Ltd, Tokyo, Japan.
Kiwamu KudoMedical Imaging Business Center, Ricoh Company, Ltd, Tokyo, Japan.
Eiichi OkumuraMedical Imaging Business Center, Ricoh Company, Ltd, Tokyo, Japan.
Hirofumi MoriseMedical Imaging Business Center, Ricoh Company, Ltd, Tokyo, Japan.
Riho NakajimaDepartment of Occupational therapy, Faculty of health science, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Ishikawa, Japan.
Mitsutoshi NakadaDepartment of Neurosurgery, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, 13 - 1 Takara-machi, Kanazawa, Ishikawa, 920-8641, Japan.

Funding

Japan Agency for Medical Research and Development JP256f0137001Japan Society for the Promotion of Science 20K17957Kanazawa University JIKO-CHOKOKU project
6 · The paper itself

Abstract

Fast periodic visual stimulation (FPVS) combined with magnetoencephalography (MEG) provides a powerful approach for extracting frequency-specific brain responses from perceptual processing areas. However, its application in cognitive paradigms, particularly those addressing visuospatial attention, remains underexplored. This study developed an FPVS-based line bisection paradigm to probe visuospatial cognition during visual exploration of the line center using eye movements without manual responses. Line stimuli were spatially modulated at high-gamma frequencies (70-90 Hz), centered at 80 Hz. Source analysis in healthy volunteers revealed a sequential pattern of cortical activation, beginning in the bilateral occipital cortices around 100 ms and subsequently involving right temporoparietal, frontal, and superior parietal regions between approximately 130 and 220 ms. Formal frequency-domain analysis confirmed that 80 Hz Morlet time-frequency power was significantly higher during stimulation than during the pre-stimulus baseline period. Functional connectivity analysis revealed task-related coupling between parietal regions and occipital, frontal, and temporal cortices. These connectivity patterns were anatomically plausible in the context of visuospatial processing. Overall, FPVS-MEG enabled temporally precise mapping of task-related cortical activity and functional coupling during visuospatial processing.

Indexed as

CognitionGamma RhythmMagnetoencephalographySpace PerceptionAdultBrain MappingFemaleHumansMalePhotic StimulationVisual PerceptionYoung AdultFast periodic visual stimulationFrequency taggingHigh gamma bandLine bisection taskMagnetoencephalographyVisuospatial cognition

Identifiers

PMID42324291
PMCPMC13562647

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.