Evidence map›Paper›PMID 42323807›Full record

ArticleAngewandte Chemie (International ed. in English)2026

Chemically Regulated STING-Activating Prodrugs of Deoxyribose Cyclic Dinucleotides Elicit Robust Immune Activation and Durable Antitumor Immunity.

Zhiqiang Xie, Huimin Liu, Yuchen Yang, Xiaohan Sun, Jingwen Wang, Tianxiang Liu, Baifan Wang, Wenrui Qiu, Yiwen Sun, Yuting Bai and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Zhiqiang XieState Key Laboratory of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Tianjin, China.
Huimin LiuSchool of Medicine, Nankai University, Tianjin, China.
Yuchen YangState Key Laboratory of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Tianjin, China.
Xiaohan SunCollege of Life Science, Tianjin Normal University, Binshuixidao 393, Tianjin, China.
Jingwen WangCollege of Life Science, Tianjin Normal University, Binshuixidao 393, Tianjin, China.
Tianxiang LiuSchool of Medicine, Nankai University, Tianjin, China.
Baifan WangState Key Laboratory of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Tianjin, China.
Wenrui QiuCollege of Life Science, Tianjin Normal University, Binshuixidao 393, Tianjin, China.
Yiwen SunState Key Laboratory of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Tianjin, China.
Yuting BaiSchool of Medicine, Nankai University, Tianjin, China.
Yao ZhangSchool of Medicine, Nankai University, Tianjin, China.
Dejun MaState Key Laboratory of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Tianjin, China.
Rong XiangSchool of Medicine, Nankai University, Tianjin, China.
Shibo LiCollege of Life Science, Tianjin Normal University, Binshuixidao 393, Tianjin, China.
Zhen XiState Key Laboratory of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Tianjin, China.ORCID 0000-0002-3332-5413

Funding

Frontiers Science Center for New Organic Matter, Nankai University 63181206Haihe Laboratory of Sustainable Chemical Transformations YYJC202102National Key Research and Development Program of China 2023YFD1700502National Natural Science Foundation of China 32270579
6 · The paper itself

Abstract

Derivatives of deoxyribose cyclic dinucleotides (dCDNs) displayed notable advantageous properties in the activation of STING pathway. The chirality of the phosphotriester of dCDN prodrugs may influence the stability, cellular permeability, bioactivity and duration, which remains inadequately explored through systematic evaluations in cellular and animal models. Herein, we isolated and characterized all three diastereoisomers of alkyne-conjugated esterase-sensitive dCDN prodrugs, and meticulously examined their difference in stability, cellular uptake and bioactivity. Within THP1 cells, the (Rp,Rp) diastereoisomer demonstrated the highest level of activation of STING pathway (EC

Indexed as

Antineoplastic AgentsMembrane ProteinsNucleotides, CyclicProdrugsAnimalscGAS-STING Signaling PathwayHumansMiceStereoisomerismSTING ProteinAntineoplastic AgentsMembrane ProteinsNucleotides, CyclicProdrugsSTING1 protein, humanSTING Proteindeoxyribose cyclic dinucleotidesdiastereoisomersprodrugsSTING agonisttumor immunotherapy

Identifiers

PMID42323807
PMCPMC13502594

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.