ReviewAnnals of biomedical engineering2026
Therapeutic Value and Optical Performance of Small-Aperture Intraocular Implants: A Systematic Review.
Review in Annals of biomedical engineering, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Digital Visual Acuity and Reading Performance with Positive and Negative Display Polarities After Bilateral Diffractive Multifocal Intraocular Lens Implantation: A Longitudinal Observational Study.Clinical ophthalmology (Auckland, N.Z.) · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionIntraocular lens (IOL) implantation is a well-established surgical procedure for managing common conditions such as cataract and refractive errors. However, conventional IOLs present several clinical challenges, including a complex lens selection process, limited tolerance to residual ametropia, and the inability to effectively correct corneal aberrations or irregular astigmatism. To overcome these limitations, a novel technology based on small-aperture optics has been developed, leveraging pinhole principles to modify depth of focus and optical system behavior. PURPOSE: To synthesize the available evidence on small-aperture intraocular implants, focusing on their therapeutic value and optical performance.
methodsA review of clinical and preclinical studies, including full-text articles, case reports and clinical trials, was conducted across databases (PubMed, Scopus, Medline, ScienceDirect, Cochrane Library, and ClinicalTrials), following the PRISMA 2020 guidelines.
resultsSmall-aperture implants improve uncorrected visual acuity, extend depth of focus, and reduce spectacle dependence. From an engineering perspective, their design reduces the impact of higher-order aberrations, thereby increasing tolerance to residual ametropias and enhancing image quality in patients with corneal irregularities, iris defects, or other anterior segment comorbidities. Overall patient-reported satisfaction is high, and both unilateral and bilateral implantation strategies are feasible. However, retinal visualization may be partially limited, and some patients may experience scotopic intolerance related to reduced light transmission. Explantation due to poor adaptation is uncommon; nevertheless, careful patient selection remains essential. No other major adverse effects have been reported.
conclusionSmall-aperture intraocular implants represent an advantageous strategy for managing multiple conditions, including presbyopia, eyes with inaccurate biometry, irregular astigmatism, and complex anterior segment disorders, particularly when conventional IOLs may be ineffective or unsuitable. By linking clinical performance to optical principles of small-aperture implants, this review provides insight into the functional rationale of small-aperture implants and informs strategies for optimized implantation.
Indexed as
Identifiers
42323773What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.