Evidence map›Paper›PMID 42323741›Full record

ReviewMedical molecular morphology2026

Lymphatic system in the liver: a new frontier in liver physiology and oncology.

Reiichiro Kondo, Rio Sonoda, Jun Akiba

Abstract readReview
PubMed Publisher
In one paragraph

Review in Medical molecular morphology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Reiichiro KondoDepartment of Pathology, Kurume University School of Medicine, 67 Asahi-machi, Kurume, Fukuoka, 830-0011, Japan. kondou_reiichirou@kurume-u.ac.jp.ORCID http://orcid.org/0000-0002-2769-7392
Rio SonodaDepartment of Pathology, Kurume University School of Medicine, 67 Asahi-machi, Kurume, Fukuoka, 830-0011, Japan.
Jun AkibaDepartment of Pathology, Kurume University School of Medicine, 67 Asahi-machi, Kurume, Fukuoka, 830-0011, Japan.

Funding

Kurume University R4 Academic Research Promotion Fund
6 · The paper itself

Abstract

The lymphatic system in the liver has long been regarded as a passive transport route responsible for interstitial fluid drainage. However, recent research has redefined it as a "new frontier in hepatology," playing active and multifaceted roles in liver disease progression, ascites formation, and tumor immune responses. In malignancies such as liver cancer, lymphatic vessels function as conduits for lymph node metastasis, while simultaneously serving as pathways for tumor antigens and tumor-induced inflammatory cells, potentially contributing to the modulation of the immune microenvironment. This review first outlines the latest findings regarding the lymphatic system in non-neoplastic tissues. Next, we examine recent studies investigating the impact of lymphatic vessels on cancer progression. Furthermore, we focus specifically on the hepatic lymphatic system in both non-neoplastic and cancerous states. Finally, we conclude by discussing the potential role of hepatic lymphatic vessels in regulating the tumor microenvironment in liver cancer.

Indexed as

Hepatocellular carcinomaIntrahepatic cholangiocarcinomaTumor-associated lymphaticsTumor microenvironmentVEGF-C

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.