Evidence map›Paper›PMID 42323669›Full record

SynthesisJournal of cardiothoracic surgery2026

Safety and feasibility of rotational atherectomy in chronic total occlusion: a systematic review and meta-analysis.

Ahmed Abdelaziz, Hanaa Elsayed, Aboalmagd Hamdaalah, Karim Atta, Ahmed Mechi, Hallas Kadhim, Aya Moustafa Aboutaleb, Ahmed Elaraby, Mohamed Hatem Ellabban, Fayed Mohamed Rzk and 11 more

Abstract readSystematic ReviewMeta-AnalysisReview
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of cardiothoracic surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Ahmed AbdelazizMedical Research group of Egypt (MRGE), Negida Academy, Arlington, MA, USA. ahmedmhmd0144@gmail.com.
Hanaa ElsayedMedical Research group of Egypt (MRGE), Negida Academy, Arlington, MA, USA.
Aboalmagd HamdaalahDamietta Faculty of Medicine, Al-Azhar University, Damietta, Egypt.
Karim AttaMedical Research group of Egypt (MRGE), Negida Academy, Arlington, MA, USA.
Ahmed MechiInternal Medicine Department, University of Kufa, Medicine College, Najaf, Iraq.
Hallas KadhimAl Muthanna university College of Medicine, Samawah, Iraq.
Aya Moustafa AboutalebMedical Research group of Egypt (MRGE), Negida Academy, Arlington, MA, USA.
Ahmed ElarabyMedical Research group of Egypt (MRGE), Negida Academy, Arlington, MA, USA.
Mohamed Hatem EllabbanMedical Research group of Egypt (MRGE), Negida Academy, Arlington, MA, USA.
Fayed Mohamed RzkMedical Research group of Egypt (MRGE), Negida Academy, Arlington, MA, USA.
Mahmoud EidMedical Research group of Egypt (MRGE), Negida Academy, Arlington, MA, USA.
Hadeer Elsaeed AboElfarhMedical Research group of Egypt (MRGE), Negida Academy, Arlington, MA, USA.
Rahma AbdElfattah IbrahimMedical Research group of Egypt (MRGE), Negida Academy, Arlington, MA, USA.
Emad Addin ZawanehMedical Research group of Egypt (MRGE), Negida Academy, Arlington, MA, USA.
Mahmoud EzzatMedical Research group of Egypt (MRGE), Negida Academy, Arlington, MA, USA.
Mohamed AbdelazizMedical Research group of Egypt (MRGE), Negida Academy, Arlington, MA, USA.
Shaimaa FadelMedical Research group of Egypt (MRGE), Negida Academy, Arlington, MA, USA.
Mohamed Yasser ElnaggarFaculty of Medicine, Mansoura University, Mansoura, Egypt.
Ahmed O SenaDepartment of Cardiovascular Medicine, Cairo University Hospitals, Cairo, Egypt.
Ahmed BahnasyHematology and Oncology Department, Mayo Clinic, Medicine, Scottsdale, AZ, USA.
Emad SingerUniversity of Texas MD Anderson, Houston, TX, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThere is a lack of data available on the feasibility of rotational atherectomy (RA) in chronic total occlusion (CTO) lesions compared to RA in non-CTO lesions. So, we aimed to study the safety and feasibility of RA in patients with CTO lesions compared to non-CTO lesions.

methodsWe searched PubMed, Scopus, Web of Science (WOS), and Ovid until March 2024. We included all relevant studies assessing RA in CTO lesions versus non-CTO lesions. The primary outcome of interest was major adverse cardiovascular events (MACE), while secondary outcomes were all-cause death, cardiac death, myocardial infarction (MI), and target-vessel revascularization (TVR). Other studied angiographic outcomes were vessel perforation, technical success, and procedural success. The pooled data was analyzed using odds ratio (OR) with its 95% CI in using a random-effect model.

resultsFour studies comprising 1925 patients were included in the analysis. The pooled analysis showed that RA in CTO lesions was associated with higher rates of vessel perforation (OR = 3.56, 95% CI: 1.59-7.98, p < 0.001) compared to the non-CTO lesions. On the other hand, no significant differences were observed regarding studied clinical outcomes and angiographic outcomes between CTO and non-CTO lesions.

conclusionRA for CTO lesions was associated with comparable clinical and angiographic outcomes. RA is a safe and feasible approach in CTO lesions, despite a higher incidence of vessel perforation. More investigations on the severity of each case should be guided in further studies.

Indexed as

Atherectomy, CoronaryCoronary OcclusionChronic DiseaseFeasibility StudiesHumansNon-CTO lesionsPCIRA; CTO lesions

Identifiers

PMID42323669
PMCPMC13531741

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.