Evidence map›Paper›PMID 42323663›Full record

ArticleInternational journal of retina and vitreous2026

Accuracy of Retinal Pigment Epithelium (RPE) undulations (Oscillatory sign) as an optical coherence tomography biomarker of acute RPE tears.

Manoj P Shettigar, Jay Chhablani, Mudit Tyagi, Ritesh Narula, Raja Narayanan

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Article in International journal of retina and vitreous, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Manoj P ShettigarWen Giving Foundation Center for Vitreo-Retinal Diseases, Anant Bajaj Retina Institute, LV Prasad Eye Institute, Kadapa, India.
Jay ChhablaniUniversity of Pittsburgh, UPMC Eye Center, Choroidal Analysis and Research (CAR) Lab, Pittsburgh, USA.
Mudit TyagiSmt. Kanuri Santhamma Center for Vitreo Retinal Diseases, Kallam Anji Reddy Campus, Anant Bajaj Retina Institute, L V Prasad Eye Institute, Hyderabad, India.
Ritesh NarulaSmt. Kanuri Santhamma Center for Vitreo Retinal Diseases, Kallam Anji Reddy Campus, Anant Bajaj Retina Institute, L V Prasad Eye Institute, Hyderabad, India.
Raja NarayananSmt. Kanuri Santhamma Center for Vitreo Retinal Diseases, Kallam Anji Reddy Campus, Anant Bajaj Retina Institute, L V Prasad Eye Institute, Hyderabad, India. dr_narayanan@hotmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo evaluate the sensitivity and specificity of Retinal Pigment Epithelium (RPE) undulations (Oscillatory sign) on Optical Coherence Tomography (OCT) and assess its potential role as a predictive OCT biomarker for RPE tears in eyes with neovascular age-related macular degeneration (nAMD).

methodsRetrospective analysis of the patients who had RPE tears following nAMD, which were documented by multimodal imaging. All cases were evaluated for RPE undulations on OCT, and the sensitivity and specificity of the Oscillatory sign in eyes with documented RPE tears were assessed.

resultsSeventy-nine eyes out of 936 eyes with nAMD, which were analyzed, were found to have RPE tears, as documented by colour fundus photographs (CFP) and fundus autofluorescence (FAF). OCT images were analyzed for RPE undulations, a sign of oscillatory activity. Thirty-eight eyes of 79 (48.1%) eyes were found to have the oscillatory sign. Oscillatory sign showed a high specificity of 98.95% and sensitivity of 48.10% for an underlying RPE tear. The negative predictive value of the Oscillatory sign was 95.39%, and the positive predictive value of 80.85%.

conclusionThe Oscillatory sign of RPE undulations is not sensitive, but it is a highly specific biomarker and can help facilitate the diagnosis of occult RPE tears.

Indexed as

Neovascular age-related macular degenerationOscillatory signRetinal pigment epithelium tearsRPE undulations

Identifiers

PMID42323663
PMCPMC13540068

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