ArticleBMC oral health2026
Evaluation of the effectiveness of the membrane composed of biodegradable polycaprolactone and polyglycolic acid layers in guided bone regeneration.
Article in BMC oral health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundThis study aimed to evaluate the efficacy of a biodegradable membrane composed of polycaprolactone (PCL) and polyglycolic acid (PGA) for guided bone regeneration in bone defects.
methodsTwelve Wistar albino rats were initially included in the study. During follow-up, 3 rats were excluded. To maintain the planned sample size, these animals were replaced with 3 additional rats. Consequently, a total of 15 rats were used, and the final statistical analyses were based on 12 rats. Twenty-four standardized bilateral parietal bone defects were created and randomly allocated to four groups. Defects received either 3D-printed PCL membranes or PCL membranes coated on the inner surface with PGA (PCL/PGA). Control defects received PCL membranes alone. Group 1 received PCL/PGA with a human-derived freeze-dried bone graft, an equine xenograft, and autologous blood. Group 2 received PCL/PGA with autologous blood. Group 3 received PCL with autologous blood. Six rats were euthanized at 4 weeks and six at 8 weeks. Histopathological and stereological analyses were performed to assess newly formed bone volume.
resultsAt week 4, Group 2 showed significantly greater newly formed bone volume and total tissue volume than all other groups (p < 0.001). At week 8, newly formed bone volume in Group 2 remained significantly greater than in Groups 1 and 3 (p < 0.001) but did not differ from the control group (p > 0.05).
conclusionIn this GBR model, the PGA-coated PCL membrane enhanced new bone formation during the early phase of bone regeneration.
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