Trial reportBMC pregnancy and childbirth2026
Management of threatened preterm labor based on cervical length: a randomized controlled trial.
Trial report in BMC pregnancy and childbirth, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
5 authors.
Funding
Abstract
backgroundA substantial proportion of women with threatened preterm labor do not deliver imminently, frequently receiving unnecessary tocolytic agents and antenatal corticosteroids. The objective of this study is to evaluate whether the use of cervical length measurement in managing threatened preterm labor can reduce inappropriate treatment.
methodsA randomized controlled trial was conducted involving patients presenting with threatened preterm labor between 24 and 33
resultsOne hundred fifteen patients were identified, and 65 cases were excluded. Among the 50 recruited cases, 26 were randomized to the expectant group and 24 to the treatment group. Expectant management leads to a significant 92% reduction in inappropriate treatment [7.7% vs. 98.5%; RR 0.08; 95% CI: 0.02-0.31]. There were significantly lower rates of maternal tachycardia, hypotension, and hypokalemia, as well as a shorter median maternal stay (p < 0.05 for all) in the expectant group.
conclusionPatients with threatened preterm labor whose cervical length is within 15-30 mm without additional cervical shortening can be safely managed expectantly. This approach reduces maternal side effects and shortens maternal hospital stays.
trial registrationThis study was retrospectively registered at the Thai Clinical Trials Registry (Registration Number: TCTR20250218004) on February 18, 2025 (Date of registration) was conducted and reported in accordance with the Consolidated Standards of Reporting Trials (CONSORT) 2010 Statement.
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