Evidence map›Paper›PMID 42323509›Full record

ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2026

Selective orexin receptor cross-over treatment increases resilience and expression of neuroplastic signaling genes.

Megan M John, J J Gale, Jazmine D W Yaeger, Holly A Gerberding, Lauren S Meyer, Gabriel L Legner, Brianna S Cox, Renée A Brummels, Sabrina M Segar, Cliff H Summers

Abstract read
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In one paragraph

Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Megan M JohnDepartment of Biology, University of South Dakota, Vermillion, SD, USA.ORCID http://orcid.org/0009-0007-6216-2899
J J GaleDepartment of Biology, University of South Dakota, Vermillion, SD, USA.ORCID http://orcid.org/0000-0002-9549-4917
Jazmine D W YaegerCellular Therapies and Stem Cell Biology Group, Sanford Research, Sioux Falls, SD, USA.ORCID http://orcid.org/0000-0001-6629-0897
Holly A GerberdingDepartment of Biology, University of South Dakota, Vermillion, SD, USA.
Lauren S MeyerDepartment of Biology, University of South Dakota, Vermillion, SD, USA.
Gabriel L LegnerDepartment of Biology, University of South Dakota, Vermillion, SD, USA.
Brianna S CoxDepartment of Biology, University of South Dakota, Vermillion, SD, USA.
Renée A BrummelsDepartment of Biology, University of South Dakota, Vermillion, SD, USA.
Sabrina M SegarDepartment of Biology, University of South Dakota, Vermillion, SD, USA.
Cliff H SummersDepartment of Biology, University of South Dakota, Vermillion, SD, USA. cliff@usd.edu.ORCID http://orcid.org/0000-0002-9051-2696

Funding

Sex Differences in the Neurobiological Significance of Orexin Stress SignalingR15MH125306 · NIMH · UNIVERSITY OF SOUTH DAKOTA · PI SUMMERS, CLIFF H · 2021 to 2021
$427k
Amygdalar Orexin Modulation of Affective DisordersR15MH104485 · NIMH · UNIVERSITY OF SOUTH DAKOTA · PI SUMMERS, CLIFF H · 2015 to 2015
$426k
National Science Foundation (NSF) DGE-1633213NIMH NIH HHS R15 MH104485NIMH NIH HHS R15 MH125306
6 · The paper itself

Abstract

Social stress, beneficial for evaluating threats and resource opportunities, influences the development of anxious and depressive disorders. Stress responses are initiated via a pro-stress circuit in the anterior region of the basolateral amygdala (aBLA). This circuit contains pyramidal glutamatergic neurons that express genetic markers Camk2α, Rspo2, and Hcrtr1, which enhance stress-vulnerable behaviors via Orx

Identifiers

PMID42323509

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.