ArticleScientific reports2026
Neuron-specific expression of transmembrane protein 130 (TMEM130).
Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Transmembrane protein 130 (TMEM130) was identified as significantly downregulated in rupture-prone intracranial aneurysm lesions in a rat model. This study aimed to characterize TMEM130 tissue distribution and physiological function in rats. RNA sequencing was conducted on rupture-prone intracranial aneurysm lesions and control arterial tissues to identify differentially expressed genes. Tmem130 mRNA spatial expression patterns were examined by in situ hybridization across multiple rat organs. A Tmem130-deficient rat line was generated using the CRISPR-Cas9 system to evaluate potential functional effects. Histological analyses and open-field behavioral tests were performed to assess neuronal morphology and locomotor or anxiety-like behavior, respectively. In situ hybridization revealed that Tmem130 expression was restricted to the brain and adrenal medulla, with widespread localization in neurons throughout cortical and subcortical regions. Here, TMEM130 was detected only in transcriptional level due to the absence of TMEM130-specific antibody. Tmem130
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