Evidence map›Paper›PMID 42323388›Full record

ArticleScientific reports2026

Preterm birth and birth weight extremes are associated with periodontal disease and tooth loss in the ARIC study.

Maria Doughan, Eung-Kwon Pae, Lisa Yanek, Omar Chehab, Bassel Doughan, Kevin Moss, James D Beck, Ronald M Harper, Erin D Michos

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Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Maria Doughan *Department of Orthodontics and Pediatric Dentistry, University of Maryland School of Dentistry, Baltimore, MD, USA.
Eung-Kwon Pae *Department of Orthodontics and Pediatric Dentistry, University of Maryland School of Dentistry, Baltimore, MD, USA.
Lisa YanekDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Omar ChehabDivision of Cardiology, Ciccarone Center for the Prevention of Cardiovascular Disease, Johns Hopkins University School of Medicine, Blalock 524-B, 600 N. Wolfe Street, Baltimore, MD, 21287, USA.
Bassel DoughanFaculty of Dental Surgery, Côte d'Azur University, Nice, France.
Kevin MossDepartment of Biostatistics and Health Data Science, Indiana University School of Medicine, Indianapolis, USA.
James D BeckDepartment of Periodontology, Endodontics, and Dental Hygiene, Adams School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Ronald M HarperDepartment of Neurobiology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
Erin D MichosDivision of Cardiology, Ciccarone Center for the Prevention of Cardiovascular Disease, Johns Hopkins University School of Medicine, Blalock 524-B, 600 N. Wolfe Street, Baltimore, MD, 21287, USA. edonnell@jhmi.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To investigate whether preterm birth (PTB) and extreme birth weights are associated with the prevalence of periodontal disease and tooth loss later in life, we conducted a cross-sectional analysis of 6152 adults (62.3 ± 5.6 years) from the Atherosclerosis Risk in Communities (ARIC) study, who underwent a periodontal examination at Visit 4 (1996-1998). Preterm birth (PTB) (< 37 weeks) and birth weight categories (low birth weight (LBW) < 2.5 kg and high birth weight (HBW) > 4.0 kg) were self‑reported. Periodontal status was assessed via clinical examination and classified using the Periodontal Profile Class (PPC). Multivariable logistic regression models estimated odds ratios (ORs) and 95% confidence intervals (CIs) for prevalent periodontal disease (PD) and tooth loss, adjusting for sociodemographic, behavioral, and cardiovascular risk factors. LBW and PTB were associated with increased odds of PD (OR = 1.57, 95% CI 1.15-2.16 and OR = 1.52, 95% CI 1.02-2.27, respectively), but not with tooth loss. Conversely, HBW was not associated with PD but was linked to greater odds of tooth loss (OR = 1.49, 95% CI 1.06-2.07). Adverse birth outcomes are associated with periodontal health in later life, supporting life-course approaches to risk assessment and prevention in both oral and systemic health.

Indexed as

Birth WeightPeriodontal DiseasesPremature BirthTooth LossAgedCross-Sectional StudiesFemaleHumansInfant, Low Birth WeightMaleMiddle AgedOdds RatioPrevalenceRisk FactorsBirth weightEpidemiologyPeriodontal diseasePreterm birthTooth loss

Identifiers

PMID42323388
PMCPMC13558688

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.