Evidence map›Paper›PMID 42323352›Full record

Articlenpj aging2026

Investigating the human anellome across the lifespan reveals sex-specific biphasic trajectories.

Yakhouba Kane, Yingying Ma, Beibei Yan, Xiuli Zhao, Ting Ge, Yanpeng Li, Le Cao, Min Zhang, Yuanyuan Pei, Zhenzhou Wan and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in npj aging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Yakhouba KaneShanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Yingying MaShanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Beibei YanMedical Laboratory, Taizhou Fourth People's Hospital, Taizhou, Jiangsu, China.
Xiuli ZhaoMedical Laboratory, Taizhou Fourth People's Hospital, Taizhou, Jiangsu, China.
Ting GeDepartment of Gastroenterology, Hepatology and Nutrition, Shanghai Children's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Yanpeng LiShanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Le CaoShanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Min ZhangShanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Yuanyuan PeiShanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Zhenzhou WanMedical Laboratory, Taizhou Fourth People's Hospital, Taizhou, Jiangsu, China. wanlv@126.com.
Ting ZhangDepartment of Gastroenterology, Hepatology and Nutrition, Shanghai Children's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. zhangt@shchildren.com.cn.
Chiyu ZhangShanghai Public Health Clinical Center, Fudan University, Shanghai, China. chiyu_zhang1999@163.com.

Funding

National Natural Science Foundation of China 32441099Shanghai Eastern Talent Plan BJWS2025082
6 · The paper itself

Abstract

Anelloviruses dominate the human plasma virome, yet their lifespan dynamics and relationships with the immune system are unclear. We integrated metagenomics with cytokines, HERV-K, and CMV profiling across 405 individuals (0-100 years) and found that prevalence, abundance, and diversity varied non-linearly with age and by sex. Alphatorqueviruses accumulated progressively with age, while betatorqueviruses and gammatorqueviruses displayed biphasic, female-specific patterns. Alphatorquevirus species diversity had significant inflection points at ages 54-58 years in females. We identified a stable core of 12 age-uniform species, with their abundance trajectories diverging significantly by sex. Male bias in anellovirus metrics widened with age, and community dispersion reversed across lifespan. CMV IgG titers correlated significantly with anellovirus genus richness. In young adult females, anellovirus ORF1 was associated with IL-1β. These findings suggest altered anellovirus ecology as a correlate of age-related immune changes, positioning these viruses as strong indicators of immune status and offering new perspectives on age-modulated host-virus dynamics.

Identifiers

PMID42323352
PMCPMC13642248

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.