ArticleScientific reports2026
Halodule uninervis ethanolic extract reduces inflammation in LPS-stimulated RAW 264.7 macrophages via NF-κB, STAT3, and MAPK modulation.
Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Medicinal plants have been used since ancient times for the treatment and prevention of various diseases. Plant-derived compounds offer a promising alternative to synthetic anti-inflammatory drugs, with potent activity and reduced toxicity. The seagrass Halodule uninervis exhibits several pharmacological properties due to the presence of various bioactive metabolites. However, its anti-inflammatory activity is not yet explored. In this study, we investigated the anti-inflammatory potential of an ethanolic extract of H. uninervis (HUE) in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages by assessing its effect on the expression and activation of different inflammatory mediators. Our results revealed that HUE inhibited the LPS-stimulated inflammatory response in macrophages by downregulating the expression of iNOS and COX-2 and reduced the expression of NO and pro-inflammatory cytokines, IL-6 and TNF-α. Moreover, the anti-inflammatory potential of HUE was associated with reduced cellular migration and the suppression of the NF-κB, STAT3, and MAPKs pathways. Altogether, H. uninervis exhibits anti-inflammatory activity in vitro and may contribute to the modulate of inflammatory responses.
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