ArticleTranslational psychiatry2026
Impact of NRSN2 deficiency on memory: Altered excitatory synaptic plasticity associated with reduced expression of NMDA receptor subunits and impaired LTP in the hippocampus.
Jialu Wei, Yongkang Wu, Yuan Yi, Yixia Gan, Haibo Li, Lingbo Wang, Yiping Shen, Yi Dong, Yu An
Abstract read
In one paragraphArticle in Translational psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
9 authors.
Jialu Wei *Human Phenome Institute, Institute of Medical Genetics and Genomics, MOE Key Laboratory of Contemporary Anthropology, Zhangjiang Fudan International Innovation Center, Fudan University, 825 Zhangheng Road, Shanghai, 201203, China.
Yongkang Wu *Key Laboratory of Adolescent Health Assessment and Exercise Intervention of Ministry of Education, East China Normal University, Shanghai, 200241, China.
Yuan YiHuman Phenome Institute, Institute of Medical Genetics and Genomics, MOE Key Laboratory of Contemporary Anthropology, Zhangjiang Fudan International Innovation Center, Fudan University, 825 Zhangheng Road, Shanghai, 201203, China.
Yixia GanKey Laboratory of Adolescent Health Assessment and Exercise Intervention of Ministry of Education, East China Normal University, Shanghai, 200241, China.
Haibo LiNingbo Key Laboratory of Genomic Medicine and Birth Defects Prevention, The Central Laboratory of Birth Defects Prevention and Control, The Affiliated Women and Children's Hospital of Ningbo University, Ningbo, 315012, China.ORCID http://orcid.org/0000-0002-9309-6632 Lingbo WangShanghai Key Laboratory of Metabolic Remodeling and Health, Institute of Metabolism and Integrative Biology, Institute of Reproduction and Development, Obstetrics and Gynecology Hospital, Fudan University, Shanghai, 200433, China.ORCID http://orcid.org/0000-0002-0962-8457 Yiping ShenDivision of Genetics and Genomics, Boston Children's Hospital, Harvard Medical School, Boston, 02115, USA.
Yi DongKey Laboratory of Adolescent Health Assessment and Exercise Intervention of Ministry of Education, East China Normal University, Shanghai, 200241, China. ydong@tyxx.ecnu.edu.cn.ORCID http://orcid.org/0000-0003-0183-4747 Yu AnHuman Phenome Institute, Institute of Medical Genetics and Genomics, MOE Key Laboratory of Contemporary Anthropology, Zhangjiang Fudan International Innovation Center, Fudan University, 825 Zhangheng Road, Shanghai, 201203, China. anyu@fudan.edu.cn.ORCID http://orcid.org/0000-0001-8051-8229 Funding
Ningbo Municipal Bureau of Science and Technology (Ningbo Science and Technology Bureau) 2023Z178Science and Technology Commission of Shanghai Municipality (Shanghai Municipal Science and Technology Commission) 2017SHZDZX01
6 · The paper itselfAbstract
Our earlier human studies identified NRSN2 (Neurensin-2), a neuronal-specific vesicular protein, as a candidate gene contributing to 20p13 microdeletion syndrome, yet the functional consequences of NRSN2 deficiency in the nervous system remain poorly understood. To explore the role of Nrsn2 in neurodevelopment and cognitive function, we utilized previously generated homozygous Nrsn2 knockout mice (Nrsn2
Indexed as
HippocampusLong-Term PotentiationMemoryNeuronal PlasticityReceptors, N-Methyl-D-AspartateAnimalsExcitatory Postsynaptic PotentialsFearMaleMaze LearningMiceMice, KnockoutPyramidal CellsReceptors, N-Methyl-D-Aspartate
Identifiers
PMID42323322
PMCPMC13530264
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