Evidence map›Paper›PMID 42323292›Full record

ArticleTranslational psychiatry2026

Mapping behavioural mechanisms linking childhood maltreatment, cognition, impulsivity, and suicidality in bipolar disorder: A network approach.

Natalia E Fares-Otero, Astrid E Iversen, Alfonso Gutiérrez-Zotes, Jeff Zarp, Esther Jiménez, Jose Sánchez-Moreno, Edith Pomarol-Clotet, Eduard Vieta, Hanne L Kjærstad, Elisabet Vilella and 1 more

Abstract read
In one paragraph

Article in Translational psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Natalia E Fares-Otero *Department of Psychiatry and Psychotherapy, Technical University of Munich, TUM School of Medicine and Health, Klinikum rechts der Isar, Munich, Germany. natalia.fares@tum.de.ORCID http://orcid.org/0000-0002-8589-7384
Astrid E Iversen *Neurocognition and Emotion Across Disorders of the Brain (NEAD) Centre, Psychiatric Centre Copenhagen, Frederiksberg Hospital, Copenhagen, Denmark.ORCID http://orcid.org/0009-0000-5484-8945
Alfonso Gutiérrez-ZotesNetwork Centre for Biomedical Research in Mental Health (CIBERSAM), Health Institute Carlos III (ISCIII), Madrid, Spain.
Jeff ZarpNeurocognition and Emotion Across Disorders of the Brain (NEAD) Centre, Psychiatric Centre Copenhagen, Frederiksberg Hospital, Copenhagen, Denmark.ORCID http://orcid.org/0000-0002-3415-8098
Esther JiménezDepartment of Psychiatry and Psychology, Bipolar and Depressive Disorders Unit, Hospital Clínic, Institute of Neurosciences, University of Barcelona (UBNeuro), Barcelona, Spain.
Jose Sánchez-MorenoDepartment of Psychiatry and Psychology, Bipolar and Depressive Disorders Unit, Hospital Clínic, Institute of Neurosciences, University of Barcelona (UBNeuro), Barcelona, Spain.ORCID http://orcid.org/0000-0003-1520-093X
Edith Pomarol-ClotetNetwork Centre for Biomedical Research in Mental Health (CIBERSAM), Health Institute Carlos III (ISCIII), Madrid, Spain.
Eduard VietaDepartment of Psychiatry and Psychology, Bipolar and Depressive Disorders Unit, Hospital Clínic, Institute of Neurosciences, University of Barcelona (UBNeuro), Barcelona, Spain.ORCID http://orcid.org/0000-0002-0548-0053
Hanne L KjærstadNeurocognition and Emotion Across Disorders of the Brain (NEAD) Centre, Psychiatric Centre Copenhagen, Frederiksberg Hospital, Copenhagen, Denmark.ORCID http://orcid.org/0000-0001-7781-8853
Elisabet VilellaNetwork Centre for Biomedical Research in Mental Health (CIBERSAM), Health Institute Carlos III (ISCIII), Madrid, Spain.ORCID http://orcid.org/0000-0002-1887-5919
Kamilla W MiskowiakNeurocognition and Emotion Across Disorders of the Brain (NEAD) Centre, Psychiatric Centre Copenhagen, Frederiksberg Hospital, Copenhagen, Denmark.ORCID http://orcid.org/0000-0003-2572-1384

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Childhood maltreatment (CM) has been consistently associated with increased risk and poorer outcomes in bipolar disorder (BD). However, the behavioural and cognitive mechanisms linking CM and suicidality remain poorly understood, limiting the development of targeted preventive interventions. We estimated a regularised partial correlation network to explore the interplay between CM subtypes (emotional, physical, or sexual abuse; emotional and physical neglect), cognitive domains (attention/processing speed, executive function/working memory, socio-emotional cognition, decision-making), impulsivity traits (attentional, motor, non-planning), and suicidal behaviours (ideation, planning, attempts) in 249 euthymic individuals with BD (mean age = 46.14, SD = 8.60; 59.84% female; 71.89% BD type I). CM was assessed using the Childhood Trauma Questionnaire (CTQ), cognition with a comprehensive neuropsychological battery, impulsivity with the Barratt Impulsiveness Scale (BIS-11), and suicidality with the Columbia Suicide Severity Rating Scale (C-SSRS) and structured interview. Age, sex, and social desirability (CTQ minimisation/denial subscale) were included as covariates. CM was associated with both cognitive functioning (poorer executive function and working memory, attention/processing speed, and socio-emotional cognition) and suicidality (suicidal ideation and, to a lesser extent, suicide attempts). Emotional abuse was linked to suicidal ideation (strongest association among CM subtypes; r = 0.27, p <0.001) and showed the highest centrality within the network (strength z = 1.76; expected influence z = 1.95). All CM subtypes were associated with impulsivity traits. Motor impulsivity emerged as a behavioural bridge between CM and suicidality (bridge expected influence z = 0.21), whereas higher socio-emotional cognition, particularly the ability to manage emotions, was associated with fewer suicide attempts. These findings highlight specific cognitive and behavioural mechanisms linking CM and suicidality in BD. Emotional abuse and socio-emotional cognition represent promising targets for trauma-informed and personalised interventions.

Indexed as

Adult Survivors of Child AbuseBipolar DisorderCognitionImpulsive BehaviorSuicidal IdeationSuicideAdultExecutive FunctionFemaleHumansMaleMiddle AgedNeuropsychological Tests

Identifiers

PMID42323292
PMCPMC13283214

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.