Evidence map›Paper›PMID 42323289›Full record

ArticleNature communications2026

Repurposing polyamines to prevent life-threatening arrhythmias in Short QT Syndrome type 3.

Ana I Moreno-Manuel, Francisco M Cruz, Álvaro Macías, Eva Cabrera-Borrego, José Jalife

Abstract read
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ana I Moreno-ManuelCentro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.ORCID http://orcid.org/0000-0002-5011-2786
Francisco M Cruz *Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.
Álvaro Macías *Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.ORCID http://orcid.org/0000-0002-9952-6947
Eva Cabrera-BorregoCentro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.ORCID http://orcid.org/0000-0003-2997-2391
José JalifeCentro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain. jjalife@cnic.es.ORCID http://orcid.org/0000-0003-0080-3500

Funding

Ministry of Economy and Competitiveness | Instituto de Salud Carlos III (Institute of Health Carlos III) PI23/01039
6 · The paper itself

Abstract

Short QT Syndrome type 3 (SQTS3) is an inherited disorder marked by an abnormally short QT interval on ECG and a high risk of life-threatening arrhythmias, for which effective targeted therapies are lacking. SQTS3 is caused by Kir2.1 mutations that enhance the outward component of the strong inward rectifier potassium current (I

Indexed as

Arrhythmias, CardiacPolyaminesPotassium Channels, Inwardly RectifyingAction PotentialsAnimalsDisease Models, AnimalElectrocardiographyHumansMaleMiceMutationKir2.1 channelPolyaminesPotassium Channels, Inwardly Rectifying

Identifiers

PMID42323289
PMCPMC13439188

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.