ArticleOptometry and vision science : official publication of the American Academy of Optometry2026
Ciliary muscle thickness and intraocular pressure before and after latanoprost.
Article in Optometry and vision science : official publication of the American Academy of Optometry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeTo test the hypothesis that a larger, latanoprost-induced intraocular pressure (IOP) reduction is associated with a thicker ciliary muscle.
methodsParticipants (N = 31) were healthy with the following details: mean ± SD age 24.8 ± 3.3 years. The ciliary muscle was imaged with anterior segment optical coherence tomography and Goldmann IOP was measured at baseline and 12-18 h after latanoprost instillation. Linear regression models of baseline IOP and IOP reduction as predicted by baseline ciliary muscle thickness were performed. Partial correlation coefficients were calculated for model predictor variables.
resultsThe mean ± SD latanoprost-induced IOP reduction was -2.6 ± 2.1 mmHg (t = -7.1, p < 0.0001). A larger reduction in IOP was significantly associated with thicker baseline maximum ciliary muscle thickness (CMTMAX) after controlling for age and baseline IOP (R
conclusionsThicker baseline CMTMAX/CMT1 was associated with larger latanoprost-induced IOP reductions and lower baseline IOP. Future studies should determine the clinical usefulness of ciliary muscle dimensions as a predictor of the response to latanoprost in glaucoma patients.
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