Evidence map›Paper›PMID 42323126›Full record

ArticleJournal of vascular surgery. Venous and lymphatic disorders2026

Clinical outcomes of anticoagulated vs nonanticoagulated patients with isolated distal deep venous thrombosis.

Benjamin Wick, Omar Sahibzada, Annie Cherner, Jose Ortiz de Elguea Lizarraga, Junji Tsukagoshi, Mitchell W Cox, Christine Shokrzadeh

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of vascular surgery. Venous and lymphatic disorders, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

7 authors.

Benjamin WickJohn Sealy School of Medicine, University of Texas Medical Branch, Galveston, TX.
Omar SahibzadaDepartment of Surgery, University of Texas Medical Branch, Galveston, TX.
Annie ChernerDepartment of Surgery, University of Texas Medical Branch, Galveston, TX.
Jose Ortiz de Elguea LizarragaDepartment of Surgery, University of Texas Medical Branch, Galveston, TX.
Junji TsukagoshiDepartment of Surgery, University of Texas Medical Branch, Galveston, TX.
Mitchell W CoxDivision of Vascular Surgery, Department of Surgery, University of Texas Medical Branch, Galveston, TX.
Christine ShokrzadehDivision of Vascular Surgery, Department of Surgery, University of Texas Medical Branch, Galveston, TX. Electronic address: cqli@utmb.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe optimal clinical management of isolated distal deep venous thrombosis (IDDVT) remains controversial as the benefits of routine anticoagulant therapy are not clearly defined amid the risk of bleeding events. Our study aimed to compare clinical outcomes between patients with IDDVT treated with anticoagulation vs those managed conservatively.

methodsWe performed a retrospective analysis of adults (≥18 years old) with IDDVT identified in the TriNetX Research Network from January 1, 2014, to January 1, 2024. Patients who received anticoagulation therapy within 1 week of diagnosis were compared with patients without anticoagulation therapy. Patients were 1:1 propensity score matched for baseline covariates, including demographics and various comorbidities. We calculated and compared odds ratios with 95% confidence intervals of pulmonary embolism (PE), gastrointestinal bleeding, intracranial bleeding at 6 months, and all-cause mortality at both 6 months and 1 year.

resultsPropensity score matching resulted in 4085 patients in each group after matching. The incidence of PE and intracranial bleeding were not significantly different between anticoagulated or nonanticoagulated patients. The risk of gastrointestinal bleeding was significantly higher in patients receiving anticoagulation at 6 months. All-cause mortality was also significantly higher at both 6 months (4.94% vs 2.09%; P < .01) and 1 year (5.85% vs 2.82; P < .01).

conclusionsIn patients with IDDVT, anticoagulation therapy did not decrease the incidence of PE. These findings suggest a more selective approach to IDDVT management rather than routine anticoagulation.

Indexed as

AnticoagulantsConservative TreatmentVenous ThrombosisAdultAgedFemaleGastrointestinal HemorrhageHumansIntracranial HemorrhagesMaleMiddle AgedPulmonary EmbolismRetrospective StudiesRisk AssessmentRisk FactorsTime FactorsAnticoagulantsAnticoagulationDeep venous thrombosisGastrointestinal bleedingMortalityPulmonary embolism

Identifiers

PMID42323126
PMCPMC13416660

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.